To obtain a new cephem compound having an excellent antibacterial power against gram-positive bacteria, especially metuicillin-resistant Staphylococcus aureus, high in solubility in water, low in toxicity, and high in safety.
For this compound, a cephem compound of formula I {R 1 is carboxyl. carboxyl; R2 is a five or six member aromatic ring group, which may contain N, S and/or O, if necessary, each having a substituent; R is a group of formula II (R3 is a lower alkyl, etc.; B- is an anion; (f) is 0, when R1 is carbodylato, or (f) is 1, when R1 is carboxyl], etc.}, its cephem carboxy- protecting ester and its non-toxic salt, for example, 7-[2-phenylacetamido]-3-[2-(1- methyl-4-pyridino)thiovinyl]-3-cephem-4-carboxylate or its salt are cited as examples. The compound of formula I is obtained by subjecting the corresponding amine compound and the corresponding carboxylic acid compound to an amide bond-forming reaction and then to a protecting group-removing reaction.
YASUI MASARU
ITO MASAHIRO
HYODO AKIO
HANAKI HIDEAKI
TAIHO PHARMACEUTICAL CO LTD
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