Title:
脳浮腫抑制剤
Document Type and Number:
Japanese Patent JP4011114
Kind Code:
B2
Abstract:
The present invention relates to a composition for treating or preventing brain edemas which comprises an endothelin antagonist as an active ingredient, for example, the compound of the following formula (I): or pharmaceutically acceptable salts or hydrates thereof, bosentan, cycloÄD-aspartyl-L-Ä3-(4-phenylpiperazin-1-ylcarbonyl)Ü-alanyl-L-aspar tyl-D-Ä2-(2thienyl)Üglycyl-L-leucyl-D-tryptophylÜdisodium or cyclo ÄD-Asp-L-Pro-D-Val-L-Leu-D-TrpÜ. Furthermore, the present invention provides a method for treating or preventing brain edemas, which comprises administering an effective amount of an endothelin antagonist and use of an endothelin antagonist in the manufacture of a medicament for treating or preventing brain edemas. An endothelin antagonist exhibits an inhibitory effect on all brain edemas regardless of the mechanism of onset and thus is highly useful in the treatment or prevention of brain edemas.
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Inventors:
Mitsuyoshi Ninomiya
Yoshiyuki Matsuo
Yoshiyuki Matsuo
Application Number:
JP53636696A
Publication Date:
November 21, 2007
Filing Date:
May 29, 1996
Export Citation:
Assignee:
Shionogi Pharmaceutical Co., Ltd.
International Classes:
A61K31/56; A61K31/00; A61K31/216; A61K31/222; A61K31/225; A61K31/506; A61K38/08; A61K38/12; A61P7/10; A61P25/28
Domestic Patent References:
JP7053484A |
Other References:
Peptide, 1994年, 15(3), 467-469
Attorney, Agent or Firm:
Hideaki Yamauchi