Title:
脳脊髄液精製システム
Document Type and Number:
Japanese Patent JP7127196
Kind Code:
B2
Abstract:
The present invention provides methods and systems for conditioning cerebrospinal fluid (CSF). The methods provide for efficiently removing target compounds from CSF. The systems provide for a multilumen flow path and exchange of a majority volume portion of CSF in the CSF space. The removal and/or delivery of specific compounds can be tailored to the pathology of the specific disease. The removal is targeted and specific, for example, through the use of specific size-exclusion thresholds, antibodies against specific toxins, and other chromatographic techniques, as well as delivery and/or removal of targeted therapeutic agents. The invention finds use as a diagnostic, therapeutic and drug delivery platform for a variety of diseases affecting the CNS by accessing the CSF space. Exemplified disease conditions treatable by the present CSF processing systems and methods include, but are not limited to: Cerebral Vasospasm, Guillain Barre Syndrome, Alzheimer's, Parkinson's, Huntington's, Multiple Sclerosis, Amyotrophic Lateral Sclerosis, Spinal Cord Injury, Traumatic Brain Injury, Stroke, Cancer affecting the brain or spinal cord, Prion disease, Encephalitis from various causes, Meningitis from various causes, diseases secondary to enzymatic or metabolic imbalances, Biological Warfare, etc. For the first time, the present invention offers patients a disease-modifying, disruptive technology treatment platform that addresses the known disease pathogenesis of a number of neurologic conditions to which there are presently limited and ineffective treatment options.
Inventors:
Sivanand P. Rudd
William C. Mobley
Calorie Nicorich
thomas sole
William C. Mobley
Calorie Nicorich
thomas sole
Application Number:
JP2021153052A
Publication Date:
August 29, 2022
Filing Date:
September 21, 2021
Export Citation:
Assignee:
Neurofluidics, Inc.
International Classes:
A61M1/00
Domestic Patent References:
| JP838595A | ||||
| JP2003250881A | ||||
| JP2002514096A | ||||
| JP2003515394A | ||||
| JP2004508109A | ||||
| JP2006511292A |
Foreign References:
| US4904237 |
Attorney, Agent or Firm:
Shusaku Yamamoto
Morishita Natsuki
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Morishita Natsuki
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto