NEW MATERIAL:Chain dienes expressed by formula I (R1 is formula II or formula III; R2 is CN, formyl or CO2R3; R3 is 1-4C alkyl).
EXAMPLE: A compound expressed by formula IV.
USE: An intermediate capable of industrially advantageously producing sarcophytol A having the action capable of resisting against promoter of carcinogenesis and the antiulcer action and capable of producing sarcophytol A from inexpensive and readily available raw material without passing through an oxidation process of methyl group in terminal position.
PREPARATION: A compound expressed by formula L obtained from a compound expressed by formula K, which is more inexpensive and readily available than sesquiterpenoid as starting raw material used in conventional method through Wittig reaction process or further reduction process, is epoxidated to give a compound expressed by formula M in formula I, which is then isomerized to provide the compound expressed by formula N in formula I. Furthermore, sarcophytol A expressed by formula IV can be inexpensively produced from the compound expressed by formula N by industrially advantageous method and large quantities.
| WO/2006/011669 | NOVEL CINNAMIC ACID RELATED COMPOUNDS |
| WO/2023/115123 | CRYSTALLINE INTERMEDIATES |
KITANO YASUNORI
MORINAKA YASUHIRO
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