Title:
荷電リポタンパク質複合体およびその使用
Document Type and Number:
Japanese Patent JP5317691
Kind Code:
B2
Abstract:
The present disclosure provides charged lipoprotein complexes that include as one component a negatively charged phospholipid that is expected to impart the complexes with improved therapeutic properties.
Inventors:
Da Souks, Gene-Louis Ash.
Application Number:
JP2008502504A
Publication Date:
October 16, 2013
Filing Date:
March 23, 2006
Export Citation:
Assignee:
Serenith Therapeutics Holding S.A.
International Classes:
A61K31/683; A61K31/685; A61K31/688; A61K38/00; A61P3/06; A61P7/02; A61P9/10; A61P9/12; A61P9/14; A61P13/12; A61P25/28; A61P29/00; A61P43/00; C07K14/775
Foreign References:
| WO2003096983A1 | ||||
| WO2003029294A1 |
Other References:
SPARKS,D.L. et al,Effect of the surface lipid composition of reconstituted LPA-I on apolipoprotein A-I structure and lecithin: cholesterol acyltransferase activity,Biochim Biophys Acta,1998年,Vol.1390, No.2,p.160-72
DAVIDSON,W.S. et al,The molecular basis for the difference in charge between pre-beta- and alpha-migrating high density lipoproteins,J Biol Chem,1994年,Vol.269, No.12,p.8959-65
STAMLER,C.J. et al,Phosphatidylinositol promotes cholesterol transport in vivo,J Lipid Res,2000年,Vol.41, No.8,p.1214-21
PAPAPANAGIOTOU A,Effects of hormone replacement therapy on the phospholipid composition of high density lipoproteins in postmenopausal women,JOURNAL OF OBSTETRICS AND GYNAECOLOGYT,THE JOURNAL OF THE INSTITUTE 以下備考,2001年 1月,V21 N1,P56-61,OF OBSTETRICS AND GYNAECOLOGY
ZHANG,W. et al,Characterization of phospholipids in pre-alpha HDL: selective phospholipid efflux with apolipoprotein A-I,J Lipid Res,1998年,Vol.39, No.8,p.1601-7
FORTE,T.M. et al,Recruitment of cell phospholipids and cholesterol by apolipoproteins A-II and A-I: formation of nascent apolipoprotein-specific HDL that differ in size, phospholipid composition, and reactivity with LCAT,J Lipid Res,1995年,Vol.36, No.1,p.148-57
NYHOLM,T. et al,Properties of palmitoyl phosphatidylcholine, sphingomyelin, and dihydrosphingomyelin bilayer membranes as reported by different fluorescent reporter molecules,Biophys J,2003年,Vol.84, No.2 Pt 1,p.987-97
DAVIDSON,W.S. et al,The molecular basis for the difference in charge between pre-beta- and alpha-migrating high density lipoproteins,J Biol Chem,1994年,Vol.269, No.12,p.8959-65
STAMLER,C.J. et al,Phosphatidylinositol promotes cholesterol transport in vivo,J Lipid Res,2000年,Vol.41, No.8,p.1214-21
PAPAPANAGIOTOU A,Effects of hormone replacement therapy on the phospholipid composition of high density lipoproteins in postmenopausal women,JOURNAL OF OBSTETRICS AND GYNAECOLOGYT,THE JOURNAL OF THE INSTITUTE 以下備考,2001年 1月,V21 N1,P56-61,OF OBSTETRICS AND GYNAECOLOGY
ZHANG,W. et al,Characterization of phospholipids in pre-alpha HDL: selective phospholipid efflux with apolipoprotein A-I,J Lipid Res,1998年,Vol.39, No.8,p.1601-7
FORTE,T.M. et al,Recruitment of cell phospholipids and cholesterol by apolipoproteins A-II and A-I: formation of nascent apolipoprotein-specific HDL that differ in size, phospholipid composition, and reactivity with LCAT,J Lipid Res,1995年,Vol.36, No.1,p.148-57
NYHOLM,T. et al,Properties of palmitoyl phosphatidylcholine, sphingomyelin, and dihydrosphingomyelin bilayer membranes as reported by different fluorescent reporter molecules,Biophys J,2003年,Vol.84, No.2 Pt 1,p.987-97
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
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