NEW MATERIAL: Compounds of formula I [R1, R2 and R5 are each H, alkyl; R3 and R4 are each H, alkyl, aminoalkyl, carboxymethyl, alkoxycarbonylbenzyl, etc.; R6 is alkylene; R7 and R8 are each H, alkyl; B and B' are each phenyl substituted by 1-3 OH, naphthyl, thienyl, etc.; A is a functional group C (C is amino, hydrazino, carboxy, alkinyl, halogen, etc.), a focus connected through the functional group C, or a component T whose content is selectively increased in a specific tissue (T is a monoclonal antibody, hormone, enzyme, growth factor, etc.].
USE: Complexing agents for complexing radioactive isotopes. The obtained metal chelate is effectively used in medical diagnosis and therapy of tumors.
PROCESS: For example, a substituted halogenide malonate of formula II (X is halogen) is reacted with an amine of formula III or formula IV to obtain the corresponding compound of formula I.
Kramp, Dr. Wolfgang
Maecke, Dr. Helmut R.