Title:
CHEMILUMINESCENT PROBES FOR IMAGING/DETECTION OF PROTEASES
Document Type and Number:
Japanese Patent JP2023038235
Kind Code:
A
Abstract:
To provide dioxetane-based chemiluminescence probes capable of detecting proteases, as well as compositions and uses thereof.SOLUTION: Provided are turn-ON dioxetane-based chemiluminescence probes based on the Schapp's adamantylidene-dioxetane probe, which are capable of detecting or imaging, more specifically, determining the presence, or measuring the level, of proteases, as well as compositions and uses thereof.SELECTED DRAWING: Figure 1A
Inventors:
Shabat, Delon
Ross-Comforti, Michael Eli
Ross-Comforti, Michael Eli
Application Number:
JP2023000803A
Publication Date:
March 16, 2023
Filing Date:
January 06, 2023
Export Citation:
Assignee:
RAMOT AT TEL AVIV UNIVERSITY LTD.
International Classes:
C07K5/06; A61K49/00; C07K5/08; C07K5/10; C07K7/06; C12Q1/02; C12Q1/37; G01N33/68
Domestic Patent References:
| JP2011095273A | 2011-05-12 |
Foreign References:
| US20130078188A1 | 2013-03-28 |
Other References:
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ACS CENT. SCI., vol. 3, JPN6022010143, March 2017 (2017-03-01), pages 349 - 358, ISSN: 0005217816
NATURE BIOTECHNOLOGY, vol. 17, JPN6023050182, 1999, pages 375 - 378, ISSN: 0005217817
ORG. BIOMOL. CHEM., vol. 15, JPN6023050183, January 2017 (2017-01-01), pages 1792 - 1800, ISSN: 0005217818
PNAS, vol. 101, no. 51, JPN6022010142, 2004, pages 17867 - 17872, ISSN: 0005125715
ACS CENT. SCI., vol. 3, JPN6022010143, March 2017 (2017-03-01), pages 349 - 358, ISSN: 0005217816
NATURE BIOTECHNOLOGY, vol. 17, JPN6023050182, 1999, pages 375 - 378, ISSN: 0005217817
ORG. BIOMOL. CHEM., vol. 15, JPN6023050183, January 2017 (2017-01-01), pages 1792 - 1800, ISSN: 0005217818
PNAS, vol. 101, no. 51, JPN6022010142, 2004, pages 17867 - 17872, ISSN: 0005125715
Attorney, Agent or Firm:
Patent Attorney Corporation Shuwa Patent Office