Chemokine cytokine fused protein and its use - National Chun Sing University

Title:

Chemokine cytokine fused protein and its use

Document Type and Number:

Japanese Patent JP6174710

Kind Code:

B2

Abstract:

The present invention provides a fusion protein, comprising a chemokine polypeptide, which is a chemokine or a receptor binding domain thereof; and a cytokine polypeptide connected to said chemokine polypeptide, which is an interleukin, a TNF-superfamily cytokine or a receptor-binding domain thereof; wherein the chemokine polypeptide and the cytokine polypeptide have a common target cell, and the fusion protein has an improved chemokine activity as compared to the chemokine polypeptide, and an improved cytokine activity as compared to the cytokine polypeptide.

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Inventors:

Daegu River
Hiroki Zhou
Zhen Rui Hong
Fan Yi-yu
Hayashi birch
Wu

Application Number:

JP2015545618A

Publication Date:

August 02, 2017

Filing Date:

December 05, 2012

Export Citation:

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Assignee:

National Chun Sing University

International Classes:

C12N15/09; C07K14/52; C07K14/55; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10

Foreign References:

WO2003035105A2
WO2001040311A1

Attorney, Agent or Firm:

Takuji Yamada
Aoyama Aoi
Michiko Matsutani
Sakurai Yoko

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