Title:
CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF
Document Type and Number:
Japanese Patent JP2015083577
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide small molecule compounds which are modulators of chemokine receptor function of treating a disease associated with aberrant leukocyte recruitment and/or activation.SOLUTION: This invention relates to an antagonist of chemokine receptor function comprising a compound represented by the formula (1) in an effective amount or physiologically acceptable salt thereof (Z is cycloalkane or non-aromatic heterocyclic group condensed to one or more aromatic ring; n is an integer of 1-4; M is >NR, >CRR, -O-CRR-O- or the like; qis an integer of 0-3; qis 0 or 1).
Inventors:
LULY JAY R
NAKASATO YOSHISUKE
OSHIMA ETSUO
HARRIMAN GERALDINE C B
CARSON KENNETH G
GHOSH SHOMIR
ELDER AMY M
MATTIA KAREN M
NAKASATO YOSHISUKE
OSHIMA ETSUO
HARRIMAN GERALDINE C B
CARSON KENNETH G
GHOSH SHOMIR
ELDER AMY M
MATTIA KAREN M
Application Number:
JP2014244379A
Publication Date:
April 30, 2015
Filing Date:
December 02, 2014
Export Citation:
Assignee:
MILLENNIUM PHARM INC
KYOWA HAKKO KIRIN CO LTD
KYOWA HAKKO KIRIN CO LTD
International Classes:
A61K31/445; C07D491/044; A61K31/4353; A61K31/438; A61K31/4427; A61K31/444; A61K31/451; A61K31/4523; A61K31/4525; A61K31/4535; A61K31/4545; A61K31/496; A61K31/506; A61K31/519; A61K31/527; A61K31/537; A61K31/5377; A61K31/55; A61K31/551; A61K31/5513; A61P1/00; A61P1/04; A61P3/10; A61P9/00; A61P9/10; A61P11/06; A61P13/12; A61P17/06; A61P19/02; A61P25/00; A61P25/28; A61P29/00; A61P31/18; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D211/52; C07D221/00; C07D223/00; C07D223/20; C07D313/00; C07D313/12; C07D337/00; C07D337/12; C07D401/06; C07D401/14; C07D405/00; C07D405/06; C07D409/06; C07D451/00; C07D471/04; C07D491/00; C07D491/04; C07D491/052; C07D493/04; C07D495/04; C07D497/04; C07D513/04; C07D519/00; A61K; A61P; C07D
Domestic Patent References:
| JP2013209393A | 2013-10-10 |
Foreign References:
| WO2001009138A2 | 2001-02-08 | |||
| WO1999037651A1 | 1999-07-29 | |||
| WO1996031469A1 | 1996-10-10 | |||
| WO1997022338A1 | 1997-06-26 | |||
| WO2000014089A1 | 2000-03-16 | |||
| WO2001009137A1 | 2001-02-08 | |||
| WO2001009138A2 | 2001-02-08 | |||
| WO1999037651A1 | 1999-07-29 | |||
| WO1996031469A1 | 1996-10-10 | |||
| WO1997022338A1 | 1997-06-26 | |||
| WO2000014089A1 | 2000-03-16 | |||
| WO2001009137A1 | 2001-02-08 |
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Tsuyoshi Sato
Hiroshi Yamazaki
Tsuyoshi Sato