Title:
ケモカイン受容体のベンゾオキサジニル-アミドシクロペンチル-複素環式モジュレーター
Document Type and Number:
Japanese Patent JP4440257
Kind Code:
B2
Abstract:
Cyclopentyl compounds linked to a benzoxazinyl group through an amido moiety utilizing the ring nitrogen of the benzoxazine, and further substituted with a heterocyclic moiety, such compounds represented by formula I: which are used to modulate the CCR-2 chemokine receptor to prevent or treat inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis; and pharmaceutical compositions comprising these compounds and the use of these compounds and compositions.
Inventors:
Goble, Stephen Day
Mills, Thunder Gi
Yang, Lifou
Alexander Pasternak
Mills, Thunder Gi
Yang, Lifou
Alexander Pasternak
Application Number:
JP2006509950A
Publication Date:
March 24, 2010
Filing Date:
April 09, 2004
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
C07D413/08; A61K31/535; A61K31/55; A61P29/00; C07D243/00; C07D265/12; C07D401/00; C07D413/00; C07D413/14; C07D417/00; C07D417/14; C07D471/04; C07D498/04; C07D519/00; A61K31/536; A61K31/551; A61P1/00; A61P7/00; A61P9/10; A61P11/00; A61P11/06; A61P17/00; A61P19/02; A61P27/14; A61P27/16; A61P31/00; A61P37/02; A61P37/08; A61P43/00; A61K; C07D
Foreign References:
| US20040167156 | ||||
| WO2002013824A1 |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura