Title:
CHIMERIC ANTIGEN RECEPTOR AND CAR-T CELLS THAT BIND BCMA
Document Type and Number:
Japanese Patent JP2022141700
Kind Code:
A
Abstract:
To provide pharmaceuticals suitable for treating diseases associated with pathogenic B cells.SOLUTION: The invention relates to an isolated chimeric antigen receptor polypeptide (CAR). The CAR comprises an extracellular antigen-binding domain, comprising an antibody or antibody fragment that binds a B Cell Maturation Antigen (BCMA) polypeptide. The CAR preferably binds an epitope comprising one or more amino acids of residues 13 to 32 of the N-terminus of human BCMA. The invention further relates to a nucleic acid molecule encoding the CAR of the invention, a genetically modified immune cell, preferably a T cell, expressing the CAR of the invention and the use of said cell in the treatment of a medical disorder associated with the presence of pathogenic B cells, such as a disease of plasma cells, and/or memory B cells, and/or mature B cells, in particular multiple myeloma, non-Hodgkin's lymphoma or autoantibody- dependent autoimmune diseases.SELECTED DRAWING: Figure 1
More Like This:
Inventors:
aluminum rheme
Uta Elisabeth Hepken
Yulia Bloom
Wolfgang Uckert
Eliza key bag
Steffen Marino
Uta Elisabeth Hepken
Yulia Bloom
Wolfgang Uckert
Eliza key bag
Steffen Marino
Application Number:
JP2022106290A
Publication Date:
September 29, 2022
Filing Date:
June 30, 2022
Export Citation:
Assignee:
Max-Delbruck-Centrum Fuhr Molecular Medzin in der Helmholz-Gemeinschaft
International Classes:
C12N15/13; A61K35/17; A61P19/02; A61P29/00; A61P35/00; A61P37/02; C07K5/083; C07K7/06; C07K7/08; C07K14/705; C07K14/725; C07K16/30; C07K19/00; C12N5/078; C12N5/0783; C12N5/10; C12N15/12; C12N15/62; C12N15/63; C12N15/86
Domestic Patent References:
| JP2015527070A | 2015-09-17 |
Foreign References:
| WO2015158671A1 | 2015-10-22 | |||
| WO2015150327A1 | 2015-10-08 | |||
| WO2016014565A2 | 2016-01-28 | |||
| WO2015166073A1 | 2015-11-05 | |||
| WO2015128653A2 | 2015-09-03 | |||
| WO2016026742A1 | 2016-02-25 | |||
| WO2015157399A1 | 2015-10-15 | |||
| WO2016014535A1 | 2016-01-28 | |||
| WO2016044811A1 | 2016-03-24 |
Attorney, Agent or Firm:
Aoki Atsushi
Shinji Mihashi
Youichi Watanabe
Nakajima Masaru
Ryotaro Takei
Hidenao Tsuda
Shinji Mihashi
Youichi Watanabe
Nakajima Masaru
Ryotaro Takei
Hidenao Tsuda
Previous Patent: Modulators of KV3 channels for treating pain
Next Patent: Pharmaceutical formulations of Bruton's tyrosine kinase inhibitors
Next Patent: Pharmaceutical formulations of Bruton's tyrosine kinase inhibitors