Title:
CHIMERIC ANTIGEN RECEPTORS AND USE METHODS THEREOF
Document Type and Number:
Japanese Patent JP2023145542
Kind Code:
A
Abstract:
To provide a heterodimeric conditionally active chimeric antigen receptor (CAR), a nucleic acid comprising a nucleotide sequence encoding CAR, and a genetically modified cell to produce the CAR.SOLUTION: Disclosed herein is a heterodimeric, conditionally active chimeric antigen receptor (CAR) comprising: a first polypeptide comprising a first member of a specific binding pair, a first modulatory domain; a first member of a dimerization pair, and a transmembrane domain interposed between the first member of a specific binding pair and the first modulatory domain; and a second polypeptide comprising a transmembrane domain, a second modulatory domain, a second member of the dimerization pair, and an intracellular signaling domain, or a CAR comprising: a first polypeptide comprising a first member of a specific binding pair, a modulatory domain, a first member of a dimerization pair, a transmembrane domain interposed between the first member of a specific binding pair and the modulatory domain; and a second polypeptide comprising a second member of the dimerization pair and an intracellular signaling domain.SELECTED DRAWING: None
Inventors:
WU CHIA-YUNG
JAMES ONUFFER
WENDELL A LIM
JAMES ONUFFER
WENDELL A LIM
Application Number:
JP2023116579A
Publication Date:
October 11, 2023
Filing Date:
July 18, 2023
Export Citation:
Assignee:
UNIV CALIFORNIA
International Classes:
C12N15/62; A61K31/436; A61K35/17; A61P29/00; A61P35/00; A61P35/02; A61P37/02; A61P37/04; A61P37/06; A61P43/00; C07K14/705; C07K19/00; C12N5/0783; C12N5/10; C12N15/13; C12N15/63
Attorney, Agent or Firm:
Hatsushi Shimizu
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Kazuya Kawamoto
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Kazuya Kawamoto