Title:
ヒト癌を処置するのに有用なキメライムノレセプター
Document Type and Number:
Japanese Patent JP4448282
Kind Code:
B2
Abstract:
The present invention relates to chimeric transmembrane immunoreceptors, named "zetakines," comprised of an extracellular domain comprising a soluble receptor ligand linked to a support region capable of tethering the extracellular domain to a cell surface, a transmembrane region and an intracellular signalling domain. Zetakines, when expressed on the surface of T lymphocytes, direct T cell activity to those specific cells expressing a receptor for which the soluble receptor ligand is specific. Zetakine chimeric immunoreceptors represent a novel extension of antibody-based immunoreceptors for redirecting the antigen specificity of T cells, with application to treatment of a variety of cancers, particularly via the autocrin/paracrine cytokine systems utilized by human maligancy. In a preferred embodiment is a glioma-specific immunoreceptor comprising the extracellular targetting domain of the IL-13Ralpha2-specific IL-13 mutant IL-13(E13Y) linked to the Fc region of IgG, the transmembrane domain of human CD4, and the human CD3 zeta chain.
Inventors:
Jensen, michael
Application Number:
JP2002585615A
Publication Date:
April 07, 2010
Filing Date:
April 30, 2002
Export Citation:
Assignee:
City of Hope
International Classes:
C12N15/09; A61K35/26; A61K38/00; A61K39/395; A61P35/00; C07K14/54; C07K14/705; C07K14/715; C07K14/725; C07K14/73; C07K16/00; C07K19/00; C12N5/08; A61K39/00
Foreign References:
| WO2000023573A1 |
Other References:
Clin. Cancer Res., (1996), Vol. 2, No. 6, p. 1001-1008
DEBINSKI,CLIN CANCER RES.,1999年10月,V5,P3143S-3147S
DEBINSKI,CLIN CANCER RES.,1999年10月,V5,P3143S-3147S
Attorney, Agent or Firm:
Shinjiro Ono
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Norihiro Fukasawa
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Norihiro Fukasawa