Title:
標的治療のためのキメラ毒素
Document Type and Number:
Japanese Patent JP4067123
Kind Code:
B2
Abstract:
The present invention relates particularly to neoplastic cells targeted chimeric toxins comprising of cell targeting moieties and cell killing moieties for recognizing and for destroying the neoplastic cells, wherein the cell targeting moieties consist of gonadotropin releasing hormone homologues and the cell killing moieties consist of Pseudomonas Exotoxin A. The present invention further relates to pharmaceutical compositions containing as an active ingredient these neoplastic cells targeted chimeric toxins and to a method for the production of these chimeric toxins. The said invention also relates to a method for cancer therapy, treating malignant carcinoma cells and benign hyperplasia including uterine leiomyoma cells, extrauterine endometrial island cells, benign hyperplasia of prostate and breast and pituitary tumor adenoma cells, by the use of the above-mentioned chimeric toxins.
Inventors:
Yarconi, rhino
Netchustan, Amots
Rover Boomgalski, Haya
Marianovsky, Irina
Netchustan, Amots
Rover Boomgalski, Haya
Marianovsky, Irina
Application Number:
JP50038898A
Publication Date:
March 26, 2008
Filing Date:
June 04, 1997
Export Citation:
Assignee:
Isamu Research Development Company of the Hebrew University of Jerusalem
International Classes:
C12N15/09; A01N37/18; A61K31/00; A61K38/00; A61K38/22; A61K38/24; A61K39/395; A61K39/40; A61K39/42; A61K39/44; A61K47/48; A61P35/00; C07H21/02; C07H21/04; C07K1/00; C07K2/00; C07K4/00; C07K5/00; C07K7/00; C07K14/00; C07K14/21; C07K14/575; C07K16/00; C07K17/00; C07K19/00; C12N5/10; C12P21/02; C12P21/04; C07K
Domestic Patent References:
| JP7508641A |
Foreign References:
| WO1993015751A1 | ||||
| WO1993008290A1 |
Other References:
Proc. Eur. Pept. Symp., (1995, Meeting date 1994), 23RD, p. 765-766,1995年
Attorney, Agent or Firm:
Hiroyuki Ikeuchi
Kimihiro Sato
Koichi Kamata
Keiji
Kimihiro Sato
Koichi Kamata
Keiji