Title:
鳥インフルエンザウイルスに対するキメラワクチン抗原
Document Type and Number:
Japanese Patent JP2009528305
Kind Code:
A
Abstract:
The present invention describes chimeric vaccine antigens against Avian Influenza virus (AI). Such vaccine antigens are based on virus subunits that are coupled to protein co-stimulatory molecules that enhance both cellular and humoral arms of the immune response. Chimeric antigens can be produced on expression systems that guarantee a correct tridimensional folding of chimeric molecules constituting the basis of the present invention. The vaccine compositions containing such antigens induce an early and strong immune response on vaccinated birds and mammalians, stimulating high titers of antibodies inhibitory of the hemagglutination and a strong cellular response specific against the virus antigen. The chimeric antigens, as well as the resulting vaccine compositions are applicable to human and animal health, as vaccines for preventive use.
Inventors:
Sanchez Ramos, Oliverto
Tread Alonso, Jorge, Robert
Diaz Archer, Damaris
Figueroa Baile, Nancy, Elena
Rodriguez Morteau, Maria, Pilar
Voloto Nordero, Carlos, Guillermo
Tread Alonso, Jorge, Robert
Diaz Archer, Damaris
Figueroa Baile, Nancy, Elena
Rodriguez Morteau, Maria, Pilar
Voloto Nordero, Carlos, Guillermo
Application Number:
JP2008556645A
Publication Date:
August 06, 2009
Filing Date:
February 28, 2007
Export Citation:
Assignee:
Centro in the Any Area Energy Biotechnology
International Classes:
C07K14/11; A61K39/215; A61P31/12; A61P31/16; C07K14/705; C12N15/09
Attorney, Agent or Firm:
Asamura patent office
Hideto Asamura
Hajime Asamura
Yukihiro Ikeda
Naganuma Akio
Kajiwara Saiko
Shinmura Morio
Kanamori Koji
Yuko Nagase
Hideto Asamura
Hajime Asamura
Yukihiro Ikeda
Naganuma Akio
Kajiwara Saiko
Shinmura Morio
Kanamori Koji
Yuko Nagase