Title:
毛管電気泳動を用いる、荷電シクロデキストリン類での薬学的化合物のキラル分離
Document Type and Number:
Japanese Patent JP4503715
Kind Code:
B2
Abstract:
The separation of enantiomeric pairs of compounds by capillary electrophoresis using highly sulfated alpha -, beta -, and gamma -Cyclodextrins as chiral selectors is described herein. These charged cyclodextrins have a higher degree of sulfation and narrower heterogeneity than previous cyclodextrin derivatives. CE analyses using highly sulfated cyclodextrins produce improved resolution of a wide variety of chiral drugs, particulaly neutral compounds and amines. The highly sulfated alpha -, beta -, and gamma -cyclodextrins produce separations which complement each other to further expand the number of neutral and basic drugs that can be resolved by capillary electrophorsis.
Inventors:
Futai Ai Chen
Gene Gee Wai Shen
Ramon A Evangelista
Chan Soo
Gene Gee Wai Shen
Ramon A Evangelista
Chan Soo
Application Number:
JP20965698A
Publication Date:
July 14, 2010
Filing Date:
July 24, 1998
Export Citation:
Assignee:
Beckman Coulter Incorporated
International Classes:
C07B57/00; C08B37/16; G01N27/447
Domestic Patent References:
| JP1315401A | ||||
| JP7113797A |
Foreign References:
| WO1997010828A1 |
Other References:
Analytical Chemistry,1996年,68,8,1360-1368
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita