PURPOSE: To provide a chirality-identifying agent comprising a tartaric acid monoamide compound and used for resolving the enantiomer mixture of a chirality-having compound such as an amino acid or a hydroxy acid in a liquid chromatography.
CONSTITUTION: A chirality-identifying agent comprises a compound of the formula [R1, R2 are alkyl (which may contain an unsaturated bond and an aromatic group or hydroxy group as a substituent), aryl, but R1, R2 are different from each other; R3 is H, alkyl, etc.; the total amount of the carbon atoms in R1, R2 and R3 is ≥8, and the tartaric acid part is optically active]. For example, (R,R)-tartaric acid-mono-1-(R)-(α-naphthyl) ethylamide. The compound of the formula is obtained by reacting a hydroxyl-protected tartaric acid, etc., with a compound of formula CH(R1)(R2)NH(R3) and subsequently removing the protecting group from the reaction product.
KITAHARA HAJIME
NAKAMURA REIKO
SEIKO FUMIKO
