Chitosan connected with a small molecule integrin antagonist for targeting delivery by covalent bond

Title:

Chitosan connected with a small molecule integrin antagonist for targeting delivery by covalent bond

Document Type and Number:

Japanese Patent JP6230199

Kind Code:

B2

Abstract:

The invention relates to the chitosan polymer derivatives of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Y, X1, X4, R1, R2, and n are defined in the detailed description and claims. The chitosan polymer derivatives of formula I bind to or associate with alpha-4-beta-1 (α4β1) and alpha-V-beta-3 (α Vβ3) integrin dimers and can be used in delivery formulations to deliver drugs, nucleic acids, or other therapeutic compounds to tissues or cells expressing such integrins.

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Inventors:

Chin Jane
Goodnow Jr. Robert Alan
Hamilton Matthew Michael
Sidri Achusarao

Application Number:

JP2014553708A

Publication Date:

November 15, 2017

Filing Date:

January 24, 2013

Export Citation:

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Assignee:

F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT

International Classes:

C08B37/08; A61K47/61

Domestic Patent References:

JP2011524446A
JP2010515678A

Foreign References:

WO2010085959A1

Other References:

Journal of Controlled Release,2010年,vol. 145,pp. 159-164
Progress in Polymer Science,2012年 5月,vol. 37,pp. 659-685

Attorney, Agent or Firm:

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto

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