PURPOSE: A cholagogue having high safety and durability of action, containing cinnamic aldehyde as an active ingredient.
CONSTITUTION: A cholagogue containing cinnamic aldehyde, a main component of cinnamon oil, as an active ingredient. After cinnamic aldehyde (A) is compared with sodium dehydrocholate (B) in terms of cholagogic action (by Wistar male rat) and acute toxicity (by -Y male mouse) and discussed, B has temporary effect in cholagogic action, and A has excellent cholagogic action and durability. A has ≥5,000mg/kg LD50 value, B has 2,050mg/kg LD50 value. A is observed to have high cholagogic action and high safety. An effective dose of cinnamic aldehyde is properly regarded to be 50W100mg per time adult and ≤3 times administration daily.
SAWADA TOKUNOSUKE
YAMAHARA JIYOUJI
