Title:
CHOLESTEROL DERIVATIVE
Document Type and Number:
Japanese Patent JP3391151
Kind Code:
B2
Abstract:
PURPOSE: To obtain the subject new derivative which is a specific cholesterol derivative having an N-carbonylimidazolyl oxyalkylene chain, can be bonded to a functional substance at its end through a covalent bond and is useful as a component for forming a cytoplastic membrane such as a liposome, etc.
CONSTITUTION: This cholesterol derivative of formula I (OA is a 2-4C oxyalkylnen group; (n) is an average number of addition mols of the oxyalkylene groups and is a positive number of 1-1,000; when (n) is ≥2, the oxyalkylene groups may be different or same and may be added in a random state or added in a block state; R is H or methyl). The derivative can be efficiently bonded to a functional substance at the end of the (poly)oxyalkylene chain through a convalent bond and is useful as a component for forming a liposome for a liquid crystal raw material, a medicine transporting material, a diagnostic, a sensor, an immobilized catalyst, etc. The compound is obtained by reacting a cholesterol of formula II with an alkylene oxide and then with N'N- carbonylimidazole.
Inventors:
Go Miyazaki
Toru Yasukochi
Akinori Suginaka
Yoshihito Kadoma
Toru Yasukochi
Akinori Suginaka
Yoshihito Kadoma
Application Number:
JP15502195A
Publication Date:
March 31, 2003
Filing Date:
June 21, 1995
Export Citation:
Assignee:
Nippon Oil & Fat Co., Ltd.
International Classes:
A61K9/127; A61K47/28; C07J9/00; C07J43/00; (IPC1-7): C07J43/00
Domestic Patent References:
| JP6126152A | ||||
| JP7101978A | ||||
| JP6271597A | ||||
| JP2225495A | ||||
| JP2200699A |
Attorney, Agent or Firm:
Sei Yanagihara