To obtain the subject medicine useful for preventing and curing cardiac infraction, cardiac failure, rheumatism, etc., by allowing to contain a specific new cephem-based compound.
This chymase-inhibitor contains an oxycephem derivative expressed by formula I [X is O, SO2; R1 is H, a (substituted) lower alkyl, etc.; R2 is H, a lower alkoxy, etc.; R3 is H a lower alkyl, etc.; R4 is a lower alkyl, a lower alkoxy, etc.; R5 is COR7 (R7 is H, etc.)] or a cefemsulfone derivative, its pharmaceutically allowable salt or its hydrate. As the compound of formula I, e.g. a compound expressed by formula II (Ra is a (substituted) phenyl, etc.; Rb is H, etc.; Rc is a (substituted) tetrazole, etc.) is cited. The compound of formula I is obtained by reacting a compound of formula III with added biphenyl diazomethane, treating the reaction product with formic acid and reacting with added m-chloroperbenzoic acid and dimethylsulfide.
NAKAJIMA MASATOSHI
KAMINAKA MASAO
KII MAKOTO
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