Title:
CIS-PLATINUM COMPLEX AND MANUFACTURE
Document Type and Number:
Japanese Patent JPS6368546
Kind Code:
A
Abstract:
Compounds of the general formula I I in which R1 represents a hydrogen atom or an alkyl group of the formula CH3(CH2)n-where n=0 to 5, R2 represents a hydrogen atom when X is a carbamoyl group, an alkyl group having 1 to 6 carbon atoms, a group, bonded in an ether-like fashion, of the formula R3-O-CH2-(CHR4)m-CH2- in which R3 is a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, R4 is a hydroxyl group or an alkyloxy group having 1 to 3 carbon atoms, and m is 0 to 2, represents a group, bonded in an ether-like fashion, of the formula H-(CH2)a-(O-(CH2)b)c- where a=0 to 4, b=1 to 4 and c=1 to 7, or R2 represents a radical, bonded in a O-glycoside fashion of the formula in which R5, R6 and R7, independently of one another, are a hydrogen atom or a hydroxyl group, and R8 is a hydrogen atom, a methyl group or a hydroxy methyl group, X represents a methylene group or a carbamoyl group or a covalent bond between R1 and the 2-carbon atom, A1 and A2 are indentical and represent the hydroxyl group, chloride, bromide, iodide, nitrate, acetate or trifluoroacetate, or A1 represents sulfate or carbonate and A2 represents H2O or A1 and A2 together represent the dianion of an organic acid such as oxalic, malonic, hydroxymalonic, ethylmalonic, 1,1- or 1,2-cyclobutanedicarboxylic, phthalic, 3- or 4-carboxyphthalic, 3,4-dicarboxyphthalic or N-(carbamoylmethyl)-iminodiacetic acid, are described, and also a process for the preparation thereof, and a medicament containg these compounds.
Inventors:
TSUENETSUKU KOORARU
KONRAATO DEEMERU
HANSU PEETAA KUREEMAA
KONRAATO DEEMERU
HANSU PEETAA KUREEMAA
Application Number:
JP22216387A
Publication Date:
March 28, 1988
Filing Date:
September 07, 1987
Export Citation:
Assignee:
BEHRINGWERKE AG
International Classes:
A61K31/28; A61K31/282; A61P35/00; C07C67/00; C07C213/00; C07C215/18; C07C215/40; C07C231/00; C07C231/12; C07C233/00; C07C233/36; C07C237/00; C07C237/06; C07C241/00; C07C247/00; C07C247/04; C07C247/12; C07F15/00; C07H15/04; C07H15/26; C07H23/00; (IPC1-7): A61K31/28; C07C91/04; C07C91/26; C07C103/183; C07C103/34; C07C103/54; C07C117/00; C07F15/00
Attorney, Agent or Firm:
Chika Takagi (2 outside)