Title:
CLEOMYCIN AND ITS PREPARATION
Document Type and Number:
Japanese Patent JPS5625197
Kind Code:
A
Abstract:
NEW MATERIAL:Antibiotic cleomycin expressed by the formula (R is the terminal amino group of cleomycin), and a nontoxic salt thereof.
EXAMPLE: 3-[(S)-1'-Phenylethylamino]propylaminocleomycin.
USE: An antitumor, an antimicrobial and a chemotherapeutic agent against cancer and microbism.
PROCESS: A strain collection No.MK68-144 (FERM-P No.4108) of Streptomyces verticillus is incubated in a culture medium containing a nutrient source, and if necessary an aliphatic primary amine of the formula X-R11-NH2 (R11 is alkylene etc.; X is basic group) having two or more basic groups in the molecule, preferably at 20W40°C and neutral pH, by the submerged spinner culture method for 2W10 days, and then the cleomycin is purified and isolated.
Inventors:
UMEZAWA HAMAO
TAKITA TOMOHISA
FUJII AKIO
MURAOKA YASUHIKO
KUNISHIMA AOI
TAKITA TOMOHISA
FUJII AKIO
MURAOKA YASUHIKO
KUNISHIMA AOI
Application Number:
JP9095179A
Publication Date:
March 10, 1981
Filing Date:
July 19, 1979
Export Citation:
Assignee:
MICROBIAL CHEM RES FOUND
International Classes:
A61K31/70; A61K31/7028; A61P31/04; C12P17/00; A61P35/00; C07H15/26; C07K9/00; C12P19/44; C12P19/60; C12R1/465; (IPC1-7): A61K31/71; C07H15/26; C12P17/18
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