クロストリジウム属細菌毒素中和剤及びその製造方法

Japanese Patent JP4021400

B2

Disclosed is a neutralizing agent for a clostridium bacterial neurotoxin and a preparation method thereof. The neutralizing agent contains a flavonol glycoside (A) or a flavonol glycoside (B). The flavonol glycoside (A) has a flavone skelton which has two hydroxyl groups at the 5 and 7 positions, at least one hydroxyl group bonding at either one of the 3', 4' and 5' positions, and an ether linkage forming glycoside at the 3 position with a carbohydrate chain containing a rutinose skelton. The flavonol glycoside (B) has also another ether linkage at the 4' position with a carbohydrate chain containing rhamnose. The neutralizing agent is prepared by separating the thearubigin fraction of black tea extract by elution with methanol/water solvent using a reverse phase liquid chromatography. A fraction eluted with methanol/water solvent containing 40% methanol and a fraction eluted with methanol/water solvent containing 60% methanol have high neutralizing activity, and at least one of them is collected.

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Sawamura Shinichi
Nishimura Masakazu
Iwao Sakane

JP2003376825A

December 12, 2007

November 06, 2003

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ITO EN Co., Ltd.

A61K31/7048; A23L3/3472; C07H17/07; A23L3/3544; A61K36/00; A61K36/18; A61P31/04; A61P39/02

名城大学農学部学術報告第37号,pp.147-156, 2001年3月30日発行
南山堂 医学大辞典(豪華版) pp.540-541,「クロストリジウム」, 1998年1月16日発行
British Journal of Pharmacology, 2001, Vol.132, No.4, pp.797-798
Pharmacology & Toxicology, 2002 April, Vol.90, No.4, pp.199-202
日本薬理学雑誌, 第120巻, 補冊1, 116P-118P, 2002年11月10日発行

Hidekazu Miyoshi
Iwa Saki Kokuni
Kawamata Sumio
Masakazu Ito
Shunichi Takahashi
Toshio Takamatsu

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