貯蔵安定性を改良するための、医薬品配合物用被覆材料および結合材料

Title:

貯蔵安定性を改良するための、医薬品配合物用被覆材料および結合材料

Document Type and Number:

Japanese Patent JP4938204

Kind Code:

B2

Abstract:

The invention relates to a process for the preparation of a coating and binding agent for oral or dermal pharmaceutical forms, essentially consisting of (a) a copolymer consisting of free-radical-polymerized C1 to C4 esters of acrylic or methacrylic acid and further (meth)acrylate monomers which contain functional tertiary ammonium groups, the coplymer being present in powdered form having an average particle size of 1-40 mum, (b) 3 to 15% by weight, based on (a), of an emulsifier having an HLB of at least 14 and (c) 5 to 50% by weight, based on (a), of a C₁₂-to C₁₈-monocarboxylic acid or a C₁₂-to C₁₈-hydroxyl compound, the components (a), (b) and (c) being blended or mixed with one another with or without addition of water and if appropriate with addition of a pharmaceutical active compound and further customary additives and the coating and binding agent being produced from the mixture by melting, casting, spreading or spraying. The invention further relates to the coating and binding agent itself.

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Inventors:

Hans-Ulrich Peterite
Christian myer
Erna Roth

Application Number:

JP2002567274A

Publication Date:

May 23, 2012

Filing Date:

February 27, 2001

Export Citation:

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Assignee:

Evonik Roehm GmbH

International Classes:

A61K47/32; A61K9/16; A61K9/28; A61K9/70; A61K31/137; A61K31/192; A61K31/21; A61K31/295; A61K31/39; A61K31/4439; A61K31/546; A61K31/55; A61K31/5513; A61K31/616; A61K31/65; A61K31/7036; A61K33/18; A61K47/04; A61K47/10; A61K47/12; A61K47/20; A61P1/02; A61P5/14; A61P9/02; A61P25/16; A61P25/22; A61P25/24; A61P29/00; A61P31/04

Domestic Patent References:

JPS52117413A	1977-10-01
JPS51112564A	1976-10-05
JPS5191317A	1976-08-10
JPS49107855A	1974-10-14
JPS412195B1
JPS3917168B1

Foreign References:

WO2000005307A1

2000-02-03

Attorney, Agent or Firm:

Takuya Kuno
Takahashi
Kimihiro Hoshi
Hiroyasu Ninomiya
Ryoichi Shino
Einzel Felix-Reinhard

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