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Title:
COCRYSTALS
Document Type and Number:
Japanese Patent JP2014001225
Kind Code:
A
Abstract:

To provide novel cocrystals of cyprodinil and pyrimethanil serving as anilinopyrimidine fungicides, which are useful in preparing stable solid dispersions.

The present invention relates to cocrystals of cyprodinil or pyrimethanil, and a cocrystal-forming carboxylic acid selected from the group consisting of benzoic acid, succinic acid, fumaric acid, maleic acid, oxalic acid, pyrazine carboxylic acid, glycolic acid, levulinic acid, (2-methylphenoxy)acetic acid, hexanedioic acid, 4-(methylamino) benzoic acid, trimethyl acetic acid, pyruvic acid, and 4-hydroxy-4'-biphenyl carboxylic acid.


Inventors:
George, Neil
James, Forrest
Pauline, Teresa Gavan
Burton, Rebecca Claire
Lee, Gregory
Application Number:
JP2013000168549
Publication Date:
January 09, 2014
Filing Date:
August 14, 2013
Export Citation:
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Assignee:
SYNGENTA LTD
International Classes:
C07C63/06; A01N25/00; A01N43/54; A01P3/00; C07C53/128; C07C55/06; C07C55/10; C07C57/145; C07C57/15; C07C59/06; C07C59/185; C07C59/19; C07C59/70; C07C65/105; C07C229/60; C07D239/42
Domestic Patent References:
JPH01113374A1989-05-02
JPH07188183A1995-07-25
Foreign References:
WO2006007448A22006-01-19
WO2004078161A12004-09-16
WO2006007448A22006-01-19
Other References:
JPN6014033116; Xiao-Hong Sun, et al.: 'Heat capacity and enthalpy of fusion of pyrimethanil laurate (C24H37N3O2)' Journal of Chemical Thermodynamics vol.36 no.10, 200410, p.895-899
JPN6014033118; Andrew V. Trask: 'An overview of pharmaceutical cocrystals as intellectual property' Molecular Pharmaceutics vol.4 no.3, 2007, p.301-309
JPN6014033114; Andrew V. Trask, et al.: 'Crystal Engineering of Organic Cocrystals by the Solid-State Grinding Approach' Topics in Current Chemistry vol.254, 2005, p.41-70
JPN6014033116; Xiao-Hong Sun, et al.: 'Heat capacity and enthalpy of fusion of pyrimethanil laurate (C24H37N3O2)' Journal of Chemical Thermodynamics vol.36 no.10, 200410, p.895-899
JPN6014033118; Andrew V. Trask: 'An overview of pharmaceutical cocrystals as intellectual property' Molecular Pharmaceutics vol.4 no.3, 2007, p.301-309
Attorney, Agent or Firm:
青木 篤
石田 敬
福本 積
古賀 哲次
渡辺 陽一
武居 良太郎
中島 勝