Title:
コイルドコイルの免疫グロブリン融合タンパク質およびその組成物
Document Type and Number:
Japanese Patent JP6952221
Kind Code:
B2
Abstract:
Disclosed herein are immunoglobulin fusion proteins comprising a first antibody region, a first therapeutic agent, and a first connecting peptide; wherein the first therapeutic agent is attached to the first antibody region by the connecting peptide; and wherein the connecting peptide does not comprise a region having beta strand secondary structure. The connecting peptide may comprise an extender peptide. The extender peptide may have an alpha helical secondary structure. The connecting peptide may comprise a linker peptide. The linker peptide may not comprise any secondary structure. Also disclosed herein are compositions comprising the immunoglobulin fusion proteins and methods for using the immunoglobulin fusion proteins for the treatment or prevention of a disease or condition in a subject.
Inventors:
One,feng
Chang, Yong
One, ing
Liu, Yang
Schulz, Peter, Gee.
Chang, Yong
One, ing
Liu, Yang
Schulz, Peter, Gee.
Application Number:
JP2019181052A
Publication Date:
October 20, 2021
Filing Date:
September 30, 2019
Export Citation:
Assignee:
The Script Research Institute
International Classes:
C07K19/00; C07K14/47; C07K14/475; C07K14/505; C07K14/61; C07K14/64; C07K16/28; C12N15/62
Domestic Patent References:
| JP2010540453A | ||||
| JP2004538283A |
Foreign References:
| US20100136032 |
Other References:
Angew Chem Int Ed Engl, Epub 2013 Jun 21, vol.52, no.32, p.8295-8298
Attorney, Agent or Firm:
Kazuhiro Kiyohara