Title:
コルヒチン誘導体
Document Type and Number:
Japanese Patent JP4699373
Kind Code:
B2
Abstract:
Certain N-deacetylcolchicine and N-deacetylthiocolchine derivatives are described wherein the 7-N position on the B ring is substituted with the group - C(O)-(CHR 4 ) m -AR, wherein m is an integer of 0-10, A is S, O, N or a covalent bond; R 1 is substituted phenyl or substituted benzoyl; optionally substituted cycloalkyl of 3-7 carbons; optionally substituted naphtyl; an optionally substituted imide ring; an optionally substituted 5 or 6 member heterocycle with at least one N, S, or O in the ring; or an optionally substituted fused heterocyclic or fused carboxyclic ring system; R 2 (at the 2-position of the A ring) is methoxy, hydroxy, or methylenedioxy when taken together with R 3 ; R 3 (at the 3-position of the A ring) is methoxy, hydroxy, a monosaccharide radical, or is methylenedioxy when taken together with R 2 ; and R 4 is H or is H or methyl when m is 1. Also dimers of such compounds are disclosed. When combined with suitable pharmaceutical excipients, these compounds are useful for treating various types of cancer.
Inventors:
Lee Si Yang
Application Number:
JP2006532413A
Publication Date:
June 08, 2011
Filing Date:
April 14, 2004
Export Citation:
Assignee:
SUTTER WEST BAY HOSPITALS
International Classes:
C07C323/41; A61K9/127; A61K31/165; A61K31/277; A61K31/345; A61K31/352; A61K31/40; A61K31/4035; A61K31/41; A61K31/436; A61K31/4406; A61K31/4409; A61K31/47; A61K31/495; A61K31/505; A61K31/5415; A61P35/00; C07C323/42; C07C323/60; C07D207/16; C07D209/48; C07D213/56; C07D213/70; C07D215/22; C07D215/52; C07D239/54; C07D257/04; C07D279/36; C07D295/10; C07D295/15; C07D307/73; C07D311/24; C07D471/04; C07H5/06
Domestic Patent References:
| JP2003526665A | ||||
| JP11501324A | ||||
| JP4224550A |
Other References:
Journal of Medicinal Chemistry,2002年,45(4),p.818-840
Helvetica Chimica Acta,1996年,79(8),p.2346-2352
Journal of Natural Products,1991年,54(2),p.632-637
Journal of Medicinal Chemistry,1983年,26(10),p.1365-1369
Cancer Treatment Reports,1977年,61(2),p.259-263
Helvetica Chimica Acta,1996年,79(8),p.2346-2352
Journal of Natural Products,1991年,54(2),p.632-637
Journal of Medicinal Chemistry,1983年,26(10),p.1365-1369
Cancer Treatment Reports,1977年,61(2),p.259-263
Attorney, Agent or Firm:
Aoyama Aoi
Mitsutaka Iwasaki
Shoji Nakajima
Mitsutaka Iwasaki
Shoji Nakajima