Title:
非アルコール性脂肪性肝炎及び肝線維症ステータスを同時に評価するバイオマーカの組み合わせ
Document Type and Number:
Japanese Patent JP7273022
Kind Code:
B2
Abstract:
The invention provides a method of diagnosing Non-Alcoholic Steatohepatitis (NASH) and/or the hepatic fibrosis status of a subject, especially a subject afflicted with Non-alcoholic fatty liver disease (NAFLD) or NASH, based on the level of only three or more particular biomarkers. The invention further provides a kit suitable for performing said method and the use of said method and methods of treating patients diagnosed in accordance with the disclosed methods.
Inventors:
Batoxelli Molina Isabel
Salipante Florian
walker roger pea
Flanagan john
Faref Michelle Janet
Salipante Florian
walker roger pea
Flanagan john
Faref Michelle Janet
Application Number:
JP2020502311A
Publication Date:
May 12, 2023
Filing Date:
July 19, 2018
Export Citation:
Assignee:
Bio-Rad Europe Gaem Beher
Bio-Rad Laboratories, Inc.
Bio-Rad Laboratories, Inc.
International Classes:
G01N33/68; A61K31/155; A61K31/166; A61K31/216; A61K31/355; A61K31/40; A61K31/4162; A61K31/426; A61K31/428; A61K31/4355; A61K31/4439; A61K31/454; A61K31/519; A61K31/53; A61K31/55; A61K31/575; A61K31/7042; A61K31/715; A61K35/20; A61K38/05; A61K38/18; A61K38/22; A61K39/395; A61P1/16; A61P43/00; G01N33/53; G16H50/20
Domestic Patent References:
| JP2013040923A |
Foreign References:
| US20170160289 | ||||
| US20110014126 | ||||
| WO2016163539A1 | ||||
| WO2010000835A1 |
Other References:
BARSIC, N. et al.,Overview and developments in noninvasive diagnosis of nonalcoholic fatty liver disease,World Journal of Gastroenterology,2012年08月14日,Vol.18, No.30,pp.3945-3954
VIRAKUL, S. et al.,Histamine induces NF-κB controlled cytokine secretion by orbital fibroblasts via histamine receptor type-1,Experimental Eye Research,2016年06月,Vol.147,pp.85-93
VIRAKUL, S. et al.,Histamine induces NF-κB controlled cytokine secretion by orbital fibroblasts via histamine receptor type-1,Experimental Eye Research,2016年06月,Vol.147,pp.85-93
Attorney, Agent or Firm:
Patent Attorney Corporation Minami Aoyama International Patent Office
Junichi Ohmori
Mitsuru Takahashi
Teppei Nakamura
Akira Orii
Masayoshi Sekine
Ayako Kaneko
Shintaro Kanayama
Ayako Chiba
Tomohisa Shiraka
Junichi Ohmori
Mitsuru Takahashi
Teppei Nakamura
Akira Orii
Masayoshi Sekine
Ayako Kaneko
Shintaro Kanayama
Ayako Chiba
Tomohisa Shiraka