Title:
COMBINATION OF HDAC INHIBITOR AND ANTIMETABOLITE
Document Type and Number:
Japanese Patent JP2014097992
Kind Code:
A
Abstract:
To provide: an organic compound for use in combination with an antimetabolite for delay of progression or treatment of a proliferative disease, especially non-solid tumor disease, specifically myelodysplastic syndrome or acute myeloid leukemia; and pharmaceutical compositions.
The invention relates to pharmaceutical compositions comprising (a) a histone deacetylase inhibitor (HDAI) and (b) an antimetabolite, for simultaneous, concurrent, separate or sequential use, for example, pharmaceutical compositions comprising combinations of N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)-ethyl]-amino]methyl]phenyl]-2E-2-propenamide with (b) 5-azacitidine.
Inventors:
PETER WISDOM ATADJA
Application Number:
JP2013269307A
Publication Date:
May 29, 2014
Filing Date:
December 26, 2013
Export Citation:
Assignee:
NOVARTIS AG
International Classes:
A61K31/4045; A61K31/706; A61K45/00; A61P35/00; A61P35/02; A61P43/00
Foreign References:
| WO2004103358A2 | 2004-12-02 |
Other References:
JPN6012063472; Ｆｒａｎｃｉｓ Ｇｉｌｅｓ ｅｔ ａｌ．: ＣＬＩＮＩＣＡＬ ＣＡＮＣＥＲ ＲＥＳＥＡＲＣＨ Ｖｏｌ． １２， Ｎｏ． １５, 20060801, ｐ． ４６２８-４６３５
JPN5010009818; Ｓｔｅｖｅｎ Ｄ Ｇｏｒｅ: ＮＡＴＵＲＥ ＣＬＩＮＩＣＡＬ ＰＲＡＣＴＩＣＥ ＯＮＣＯＬＯＧＹ Ｖｏｌ． ２ ＳＵＰＰＬ． １, 200512, ｐ． Ｓ３０-Ｓ３５
JPN6012063474; Ｇｕｉｌｌｅｒｍｏ Ｇａｒｃｉａ-Ｍａｎｅｒｏ ｅｔ ａｌ．: ＢＬＯＯＤ Ｖｏｌ． １０８， Ｎｏ． １０, 20061115, ｐ． ３２７１-３２７９
JPN6012063482; Ｓｔｅｖｅｎ Ｄ． Ｇｏｒｅ ｅｔ ａｌ．: ＢＬＯＯＤ Ｖｏｌ． １０８, 200611, Ａｂｓｔｒａｃｔ ５１７
JPN6012063475; Ｓｔｅｖｅｎ Ｄ． Ｇｏｒｅ ｅｔ ａｌ．: ＣＡＮＣＥＲ ＲＥＳＥＡＲＣＨ Ｖｏｌ． ６６， Ｎｏ． １２, 20060615, ｐ． ６３６１-６３６９
JPN6012063477; Ｇｉｕｓｅｐｐｅ Ｌｅｏｎｅ ｅｔ ａｌ．: ＨＡＥＭＡＴＯＬＯＧＩＣＡ Ｖｏｌ． ８７， Ｎｏ． １２, 200212, ｐ． １３２４-１３４１
JPN6012063478; Ｓｅｐｉｄｅｈ Ｓｈａｋｅｒ ｅｔ ａｌ．: ＬＥＵＫＥＭＩＡ ＲＥＳＥＡＲＣＨ Ｖｏｌ． ２７， Ｎｏ． ５, 2003, ｐ． ４３７-４４４
JPN6012063480; Ｋａｐｉｌ Ｂｈａｌｌａ ｅｔ ａｌ．: ＢＥＳＴ ＰＲＡＣＴＩＣＥ ＆ ＲＥＳＥＡＲＣＨ ＣＬＩＮＩＣＡＬ ＨＡＥＭＡＴＯＬＯＧＹ Ｖｏｌ． １７， Ｎｏ． ４, 2004, ｐ． ５９５-６１１
JPN5010009818; Ｓｔｅｖｅｎ Ｄ Ｇｏｒｅ: ＮＡＴＵＲＥ ＣＬＩＮＩＣＡＬ ＰＲＡＣＴＩＣＥ ＯＮＣＯＬＯＧＹ Ｖｏｌ． ２ ＳＵＰＰＬ． １, 200512, ｐ． Ｓ３０-Ｓ３５
JPN6012063474; Ｇｕｉｌｌｅｒｍｏ Ｇａｒｃｉａ-Ｍａｎｅｒｏ ｅｔ ａｌ．: ＢＬＯＯＤ Ｖｏｌ． １０８， Ｎｏ． １０, 20061115, ｐ． ３２７１-３２７９
JPN6012063482; Ｓｔｅｖｅｎ Ｄ． Ｇｏｒｅ ｅｔ ａｌ．: ＢＬＯＯＤ Ｖｏｌ． １０８, 200611, Ａｂｓｔｒａｃｔ ５１７
JPN6012063475; Ｓｔｅｖｅｎ Ｄ． Ｇｏｒｅ ｅｔ ａｌ．: ＣＡＮＣＥＲ ＲＥＳＥＡＲＣＨ Ｖｏｌ． ６６， Ｎｏ． １２, 20060615, ｐ． ６３６１-６３６９
JPN6012063477; Ｇｉｕｓｅｐｐｅ Ｌｅｏｎｅ ｅｔ ａｌ．: ＨＡＥＭＡＴＯＬＯＧＩＣＡ Ｖｏｌ． ８７， Ｎｏ． １２, 200212, ｐ． １３２４-１３４１
JPN6012063478; Ｓｅｐｉｄｅｈ Ｓｈａｋｅｒ ｅｔ ａｌ．: ＬＥＵＫＥＭＩＡ ＲＥＳＥＡＲＣＨ Ｖｏｌ． ２７， Ｎｏ． ５, 2003, ｐ． ４３７-４４４
JPN6012063480; Ｋａｐｉｌ Ｂｈａｌｌａ ｅｔ ａｌ．: ＢＥＳＴ ＰＲＡＣＴＩＣＥ ＆ ＲＥＳＥＡＲＣＨ ＣＬＩＮＩＣＡＬ ＨＡＥＭＡＴＯＬＯＧＹ Ｖｏｌ． １７， Ｎｏ． ４, 2004, ｐ． ５９５-６１１
Attorney, Agent or Firm:
Takuji Yamada
Aoyama Aoi
Michiko Matsutani
Mitsutaka Iwasaki
Aoyama Aoi
Michiko Matsutani
Mitsutaka Iwasaki