Title:
COMBINATION OF IMMUNO GENE THERAPY AND CHEMOTHERAPY FOR TREATMENT OF CANCER AND HYPERPROLIFERATIVE DISEASES
Document Type and Number:
Japanese Patent JP2014169305
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a novel combinational approach for the treatment of cancer comprising a nucleic acid based therapeutic delivered with a polymeric carrier and at least one chemotherapeutic agent, for the treatment of mammalian cancer or hyperproliferative disorders.SOLUTION: This invention relates to: pharmaceutical compositions comprising a nucleic acid, a gene delivery polymer, and at least one adjunctive chemotherapeutic drug; and a method for the treatment of mammalian cancer or hyperproliferative disorders by intratumoral, intraperitoneal or systemic injection, in which the gene delivery polymer is a lipopolymer comprising a polyethylenimine backbone covalently linked with a lipid and a polyethylene glycol, and at least one pharmaceutical agent for the treatment of cancer or hyperproliferative disorders. The pharmaceutical agent is selected from the group consisting of chemotherapeutic drugs, anti-angiogenic agents, anti-cancer peptides, monoclonal antibodies and mixtures thereof.
Inventors:
FEWELL JASON G
MATAR MAJED
RICE JENNIFER
LEWIS DANNY H
ANWER KHURSHEED
MATAR MAJED
RICE JENNIFER
LEWIS DANNY H
ANWER KHURSHEED
Application Number:
JP2014092250A
Publication Date:
September 18, 2014
Filing Date:
April 28, 2014
Export Citation:
Assignee:
EGEN INC
International Classes:
A61K31/7088; A61K31/7105; A61K31/711; A61K33/243; A61K39/395; A61K45/00; A61K47/18; A61K47/32; A61K47/34; A61K47/36; A61K47/40; A61K47/42; A61K47/44; A61K48/00; A61P35/00; A61P35/04; C12N15/87
Domestic Patent References:
| JP2004515461A | 2004-05-27 | |||
| JP5704788B2 | 2015-04-22 |
Foreign References:
| US20040142474A1 | 2004-07-22 |
Other References:
JPN6011033837; 押川克久 他: '肺癌の遺伝子治療' 週刊医学のあゆみ Ｖｏｌ．１８８， Ｎｏ．７, 1999, ｐ．７６８-７６９
JPN6011033839; ＪＡＮＡＴ-ＡＭＳＢＵＲＹ，Ｍ．Ｍ． ｅｔ ａｌ: 'Ｃｏｍｂｉｎａｔｉｏｎ ｏｆ ｌｏｃａｌ， ｎｏｎｖｉｒａｌ ＩＬ１２ ｇｅｎｅ ｔｈｅｒａｐｙ ａｎｄ ｓｙｓｔｅｍｉｃ ｐａｃｌｉｔａｘｅｌ ｔｒｅａｔｍｅｎｔ ｉｎ ａ ｍｅｔａｓｔａｔｉｃ ｂ' Ｍｏｌｅｃｕｌａｒ ｔｈｅｒａｐｙ Ｖｏｌ．９， Ｎｏ．６, 200406, ｐ．８２９-３６
JPN6011033842; ＺＡＧＯＺＤＺＯＮ，Ｒ． ｅｔ ａｌ: 'Ｅｆｆｅｃｔｉｖｅ ｃｈｅｍｏ-ｉｍｍｕｎｏｔｈｅｒａｐｙ ｏｆ Ｌ１２１０ ｌｅｕｋｅｍｉａ ｉｎ ｖｉｖｏ ｕｓｉｎｇ ｉｎｔｅｒｌｅｕｋｉｎ-１２ ｃｏｍｂｉｎｅｄ ｗｉｔｈ ｄｏｘｏｒｕｂｉｃ' Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｊｏｕｒｎａｌ ｏｆ Ｃａｎｃｅｒ Ｖｏｌ．７７， Ｎｏ．５, 1998, ｐ．７２０-７２７
JPN6011033843; 漆崎一朗: '特集 サイトカインと癌化学療法 サイトカインと抗癌剤の併用理論と実際' 化学療法の領域 Ｖｏｌ．１０， Ｎｏ．６, 1994, ｐ．１０３１-１０３７
JPN6011033839; ＪＡＮＡＴ-ＡＭＳＢＵＲＹ，Ｍ．Ｍ． ｅｔ ａｌ: 'Ｃｏｍｂｉｎａｔｉｏｎ ｏｆ ｌｏｃａｌ， ｎｏｎｖｉｒａｌ ＩＬ１２ ｇｅｎｅ ｔｈｅｒａｐｙ ａｎｄ ｓｙｓｔｅｍｉｃ ｐａｃｌｉｔａｘｅｌ ｔｒｅａｔｍｅｎｔ ｉｎ ａ ｍｅｔａｓｔａｔｉｃ ｂ' Ｍｏｌｅｃｕｌａｒ ｔｈｅｒａｐｙ Ｖｏｌ．９， Ｎｏ．６, 200406, ｐ．８２９-３６
JPN6011033842; ＺＡＧＯＺＤＺＯＮ，Ｒ． ｅｔ ａｌ: 'Ｅｆｆｅｃｔｉｖｅ ｃｈｅｍｏ-ｉｍｍｕｎｏｔｈｅｒａｐｙ ｏｆ Ｌ１２１０ ｌｅｕｋｅｍｉａ ｉｎ ｖｉｖｏ ｕｓｉｎｇ ｉｎｔｅｒｌｅｕｋｉｎ-１２ ｃｏｍｂｉｎｅｄ ｗｉｔｈ ｄｏｘｏｒｕｂｉｃ' Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｊｏｕｒｎａｌ ｏｆ Ｃａｎｃｅｒ Ｖｏｌ．７７， Ｎｏ．５, 1998, ｐ．７２０-７２７
JPN6011033843; 漆崎一朗: '特集 サイトカインと癌化学療法 サイトカインと抗癌剤の併用理論と実際' 化学療法の領域 Ｖｏｌ．１０， Ｎｏ．６, 1994, ｐ．１０３１-１０３７
Attorney, Agent or Firm:
Ono Shinjiro
Kobayashi 泰
Noriko Tsujimoto
Kobayashi 泰
Noriko Tsujimoto