Title:
血栓性心血管イベントの危険がある患者におけるシクロオキシゲナーゼ-2に媒介される疾患又は病態を治療するための併用療法
Document Type and Number:
Japanese Patent JP2007519641
Kind Code:
A
Abstract:
The invention is directed to a method for treating a cyclooxygenase-2 mediated disease or condition in a mammalian patient at risk of a thrombotic cardiovascular event, wherein the patient is on aspirin therapy to reduce the risk of the thrombotic cardiovascular event, comprising orally concomitantly or sequentially administering to the patient a cyclooxygenase-2 selective inhibitor in an amount effective to treat the cyclooxygenase-2 mediate disease or condition, and a nitric oxide donating compound in accordance with Formula I or a pharmaceutically acceptable salt thereof, wherein the nitric oxide donating compound is administered in an amount effective to reduce the gastrointestinal toxicity caused by the combination of the cyclooxygenase-2 selective inhibitor and aspirin. Pharmaceutical compositions are also encompassed.
Inventors:
Dou Flaine, Claude
Belle serette, curl
Li, Lean Hai
Guay, Daniel
Gear Run, Michel
Racombe, Patrick
Aspirothace, Lenny
One, two ain
Stuyulino, Claudio Ef
Belle serette, curl
Li, Lean Hai
Guay, Daniel
Gear Run, Michel
Racombe, Patrick
Aspirothace, Lenny
One, two ain
Stuyulino, Claudio Ef
Application Number:
JP2006549813A
Publication Date:
July 19, 2007
Filing Date:
January 25, 2005
Export Citation:
Assignee:
Merck Frost Company
International Classes:
A61K45/00; A61K31/04; A61K31/045; A61K31/19; A61K31/192; A61K31/196; A61K31/216; A61K31/22; A61K31/24; A61K31/365; A61K31/42; A61K31/444; A61K31/616; A61K31/63; A61K45/06; A61P9/04; A61P9/10; A61P15/08; A61P19/02; A61P19/06; A61P25/04; A61P29/00; A61P43/00; C07C203/04; C07C205/57; C07C317/44
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura