COMBINATION THERAPY FOR TREATMENT OF OCULAR NEOVASCULAR DISORDER

Title:

COMBINATION THERAPY FOR TREATMENT OF OCULAR NEOVASCULAR DISORDER

Document Type and Number:

Japanese Patent JP2012072152

Kind Code:

A

Abstract:

To provide a pharmaceutical composition applicable to a patient diagnosed with or at high risk for developing a neovascular disorder.

The pharmaceutical composition contains a PDGF antagonist that is a PEGylated or anti-PDGF aptamer having the sequence CAGGCUACGN CGTAGAGCAU CANTGATCCU GT having 2'-fluoro-2'-deoxyuridine at positions 6, 20 and 30, 2'-fluoro-2'-deoxycytidine at positions 8, 21, 28, and 29, 2'-O-Methyl-2'-deoxyguanosine at positions 9, 15, 17, and 31, 2'-O-Methyl-2'-deoxyadenosine at position 22, "N" in positions 10 and 23 from a hexaethylene-glycol phosphoramidite, and an inverted orientation T (i.e., 3'-3'-linked) at position 32; a VEGF antagonist that is a human anti-VEGF-A antibody, bevacizumab, or binding fragment thereof, ranibizumab; and a pharmaceutically acceptable carrier.

Inventors:

SHIMA DAVID
CALIAS PERRY
ADAMIS ANTHONY P

Application Number:

JP2011236920A

Publication Date:

April 12, 2012

Filing Date:

October 28, 2011

Export Citation:

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Assignee:

OPHTHOTECH CORP

International Classes:

A61K31/711; A61K31/00; A61K31/52; A61K31/7088; A61K38/00; A61K39/395; A61K45/00; A61K45/06; A61K47/48; A61P9/00; A61P27/02; A61P43/00; C12N15/113; C12N15/115

Domestic Patent References:

JP2002543093A

2002-12-17

Foreign References:

US6051698A	2000-04-18
US6011020A	2000-01-04
US6147204A	2000-11-14

Other References:

JPN7010003195; ＢＥＲＧＥＲＳ，Ｇ．　ｅｔ　ａｌ: 'Ｂｅｎｅｆｉｔｓ　ｏｆ　ｔａｒｇｅｔｉｎｇ　ｂｏｔｈ　ｐｅｒｉｃｙｔｅｓ　ａｎｄ　ｅｎｄｏｔｈｅｌｉａｌ　ｃｅｌｌｓ　ｉｎ　ｔｈｅ　ｔｕｍｏｒ　ｖａｓｃｕｌａｔｕｒｅ　ｗｉｔｈ　ｋｉｎａｓｅ　ｉｎｈｉ' Ｊ　Ｃｌｉｎ　ＩｎｖｅｓｔＶｏｌ．１１１，　Ｎｏ．９, 200305, ｐ．１２８７-９５
JPN6010058166; ＫＯＹＡＭＡ，Ｎ．　ｅｔ　ａｌ: 'Ｍｉｇｒａｔｏｒｙ　ａｎｄ　ｐｒｏｌｉｆｅｒａｔｉｖｅ　ｅｆｆｅｃｔ　ｏｆ　ｐｌａｔｅｌｅｔ-ｄｅｒｉｖｅｄ　ｇｒｏｗｔｈ　ｆａｃｔｏｒ　ｉｎ　ｒａｂｂｉｔ　ｒｅｔｉｎａｌ　ｅｎｄｏｔｈｅｌｉａｌ　ｃ' Ｊ　Ｃｅｌｌ　ＰｈｙｓｉｏｌＶｏｌ．１５８，　Ｎｏ．１, 1994, ｐ．１-６
JPN6010058167; ＣＨＡＬＡＭ，Ｋ．Ｖ．　ｅｔ　ａｌ: 'Ａｎｔｉ　ｐｌａｔｅｌｅｔ　ｄｅｒｉｖｅｄ　ｇｒｏｗｔｈ　ｆａｃｔｏｒ　ａｎｔｉｂｏｄｙ　ｉｎｈｉｂｉｔｓ　ｒｅｔｉｎａｌ　ｐｉｇｍｅｎｔ　ｅｐｉｔｈｅｌｉａｌ　ｃｅｌｌ　ｉｎｄｕｃｅｄ　ｃｏｌｌａｇ' ＩＯＶＳＶｏｌ．３９，　Ｎｏ．４, 1998, ｐ．Ｓ８６４
JPN7013002450; ＹＯＳＨＩＤＡ，Ｓ．　ｅｔ　ａｌ: 'Ｉｎｖｏｌｖｅｍｅｎｔ　ｏｆ　ｉｎｔｅｒｌｅｕｋｉｎ-８，　ｖａｓｃｕｌａｒ　ｅｎｄｏｔｈｅｌｉａｌ　ｇｒｏｗｔｈ　ｆａｃｔｏｒ，　ａｎｄ　ｂａｓｉｃ　ｆｉｂｒｏｂｌａｓｔ　ｇｒｏｗｔｈ　ｆａｃｔｏｒ' Ｍｏｌ　Ｃｅｌｌ　ＢｉｏｌＶｏｌ．１７，　Ｎｏ．７, 1997, ｐ．４０１５-２３
JPN7014000108; Ｄａｔａｂａｓｅ　ＢＩＯＳＩＳ　ＤＮ　ＰＲＥＶ２００３００１４３６５２ , 2002

Attorney, Agent or Firm:

Yoshio Kawaguchi
Chihiro Watanabe
Katsuma Osaki

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