Title:
COMBINATION VECTORS AND METHODS FOR TREATING CANCER
Document Type and Number:
Japanese Patent JP2022051775
Kind Code:
A
Abstract:
To provide combination vectors and methods for treating cancer.SOLUTION: A composition for treating cancer is disclosed. The composition comprises a lentiviral particle and an aminobisphosphonate drug. The lentiviral particle is capable of infecting a target cell such as a cancer cell, and comprises an envelop protein optimized to target such a target cell as well as a viral vector. The viral vector comprises a small RNA optimized for targeting an FDPS mRNA sequence. The aminobisphosphonate drug includes zoledronic acid.SELECTED DRAWING: None
Inventors:
TYLER LAHUSEN
LIOU MEI-LING
XIAO LINGZHI
LI HAISHAN
CHARLES DAVID PAUZA
LIOU MEI-LING
XIAO LINGZHI
LI HAISHAN
CHARLES DAVID PAUZA
Application Number:
JP2022006999A
Publication Date:
April 01, 2022
Filing Date:
January 20, 2022
Export Citation:
Assignee:
AMERICAN GENE TECH INT INC
International Classes:
C12N15/86; A61K31/675; A61K35/76; A61K47/66; A61K48/00; A61P35/00; C07K14/155; C12N7/01; C12N15/113; C12N15/867
Domestic Patent References:
| JP2015518838A | 2015-07-06 | |||
| JP2007527240A | 2007-09-27 | |||
| JP2016502404A | 2016-01-28 | |||
| JP7017247B2 | 2022-02-08 |
Foreign References:
| WO2015017755A1 | 2015-02-05 | |||
| US20080293142A1 | 2008-11-27 |
Other References:
LI, J. ET AL.: "Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognit", THE JOURNAL OF IMMUNOLOGY, vol. Vol. 182(12), JPN6021004882, 2009, pages 8118 - 8124, ISSN: 0004957169
UEDA M. ET AL.: "CD47-dependent molecular mechanisms of blood outgrowth endothelial cell attachment on cholesterol-mo", BIOMATERIALS, vol. Vol. 31(25), JPN6022055651, 2010, pages 6394 - 6399, ISSN: 0004957170
WANG, Y. ET AL.: "Intravenous delivery of siRNA targeting CD47 effectively inhibits melanoma tumor growth and lung met", MOLECULAR THERAPY, vol. Vol. 21(10), JPN6021004884, 2013, pages 1919 - 1929, ISSN: 0004957171
UEDA M. ET AL.: "CD47-dependent molecular mechanisms of blood outgrowth endothelial cell attachment on cholesterol-mo", BIOMATERIALS, vol. Vol. 31(25), JPN6022055651, 2010, pages 6394 - 6399, ISSN: 0004957170
WANG, Y. ET AL.: "Intravenous delivery of siRNA targeting CD47 effectively inhibits melanoma tumor growth and lung met", MOLECULAR THERAPY, vol. Vol. 21(10), JPN6021004884, 2013, pages 1919 - 1929, ISSN: 0004957171
Attorney, Agent or Firm:
Shusaku Yamamoto
Morishita Natsuki
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Morishita Natsuki
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto