Title:
抗ムスカリン剤およびコルチコステロイドを含む組合せ剤
Document Type and Number:
Japanese Patent JP5032984
Kind Code:
B2
Abstract:
Combination (I) comprises a phosphodiesterase inhibitor 4 (PDE4) (A) and an antagonist of M3 muscarinic receptors (B) (3(R)-(2-hydroxy-2, 2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo [2.2.2] octane), in the form of a salt having an anion X (anion of a mono or polyvalent acid). An independent claim is also included for a method of treating a patient suffering from or susceptible to a respiratory disease or condition which responds to M3 antagonism comprising simultaneous, concurrent, separate or sequential administration of (I). ACTIVITY : Antiasthmatic; Respiratory-Gen.; Antiinflammatory. MECHANISM OF ACTION : Phosphodiesterase-4 inhibitor; Muscarinic receptors antagonist; Leukotriene-D4 antagonist; Neurokinin-1- receptor antagonist; Epidermal growth factor receptor kinase inhibitor; Beta-2 agonist; p38 Kinase inhibitor.
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Inventors:
Jordi Glass Escaldo
Jess Lenas Calvo
Hamish Rider
Pio Orbis Diaz
Jess Lenas Calvo
Hamish Rider
Pio Orbis Diaz
Application Number:
JP2007513839A
Publication Date:
September 26, 2012
Filing Date:
May 31, 2005
Export Citation:
Assignee:
Almirall, S.A.
International Classes:
A61K31/439; A61K31/137; A61K31/167; A61K31/56; A61K31/573; A61K31/58; A61K31/655; A61K45/00; A61K45/06; A61P11/00; A61P43/00
Domestic Patent References:
| JP2003504368A | ||||
| JP2000505430A | ||||
| JP2002521371A |
Foreign References:
| WO2003000241A1 | ||||
| WO2002053564A1 |
Attorney, Agent or Firm:
Mitsuo Tanaka
Takuji Yamada
Mitsutaka Iwasaki
Takuji Yamada
Mitsutaka Iwasaki