Title:
共通リンパ管内皮および血管内皮受容体-1(CLEVER-1)およびその用途
Document Type and Number:
Japanese Patent JP4387797
Kind Code:
B2
Abstract:
A novel protein Common Lymphatic Endothelial and Vascular Endothelial Receptor-1 (CLEVER-1) is described. CLEVER-1 mediates leukocyte and malignant cell binding to vascular and lymphoid endothelial cells. CLEVER-1 is the first protein that has been reported to mediate both influx into and efflux from the lymph nodes. Also provided are methods of treating inflammation and preventing metastasis of malignant cells by providing an inhibitor of CLEVER-1 binding.
Inventors:
Yarkanen, Silpa
Ilyara, Heikki
Salmi, marco
Ilyara, Heikki
Salmi, marco
Application Number:
JP2003557489A
Publication Date:
December 24, 2009
Filing Date:
January 08, 2003
Export Citation:
Assignee:
Fallon Pharmaceuticals Osamu Yukiture
International Classes:
C07K14/705; G01N33/50; A61K39/395; A61K45/00; A61P29/00; A61P35/00; A61P35/04; A61P43/00; C07K16/28; C12N15/02; C12P21/08; C12Q1/02; G01N33/15; G01N33/53; G01N33/574
Other References:
DNA Research, 1996, Vo. 3, No. 5, p. 321-329
Attorney, Agent or Firm:
Sota Asahina
Fumio Akiyama
Koji Yashima
Fumio Akiyama
Koji Yashima