Title:
複合体
Document Type and Number:
Japanese Patent JP5924795
Kind Code:
B2
Abstract:
The present invention relates to a conjugate comprising an anti-EGFR1 antibody or an EGFR binding fragment thereof and at least one dextran derivative, wherein the dextran derivative comprises at least one D-glucopyranosyl unit, wherein at least one carbon selected from carbon 2, 3 or 4 of the at least one D-glucopyranosyl unit is substituted by a substituent of the formula —O—(CH2)”—S—Bi2Hii2− wherein n is in the range of 3 to 10; and the dextran derivative is bound to the anti-EGFR antibody or an EGFR1 binding fragment thereof via a bond formed by a reaction between at least one aldehyde group formed by oxidative cleavage of a D-glucopyranosyl unit of the dextran derivative and an amino group of the anti-EGFR1 antibody or an EGFR1 binding fragment thereof.
Inventors:
Leppannen Anne
Ekholm Philip S.
Hyelin Spear
Salo Hannah
Canerva Ann
Ekholm Philip S.
Hyelin Spear
Salo Hannah
Canerva Ann
Application Number:
JP2015119792A
Publication Date:
May 25, 2016
Filing Date:
June 12, 2015
Export Citation:
Assignee:
Tenboron oy
International Classes:
C07K16/28; A61K33/22; A61K39/395; A61K41/00; A61K47/48; A61K49/00; A61K51/00; A61P35/00; C12N15/09
Other References:
Bioconjugate Chem., 2004, vol.15, no.185-194
Attorney, Agent or Firm:
Masayuki Masabayashi
Hayashi Ichiyoshi
Tetsuo Shiba
Iwaike Mitsuru
Hayashi Ichiyoshi
Tetsuo Shiba
Iwaike Mitsuru