COMPOSITE PARTICLE USED FOR DRUG DELIVERY SYSTEM

Title:

COMPOSITE PARTICLE USED FOR DRUG DELIVERY SYSTEM

Document Type and Number:

Japanese Patent JP2008195653

Kind Code:

A

Abstract:

To provide a composite particle producing hydroxy radicals in an aqueous solution by irradiation of ultrasonic waves and further making dispersion stability under neutral physiological conditions in a living body compatible with functions to specifically recognize a specified biological tissue in a well-balanced state.

The composite particle has TiO2 particles producing the hydroxy radicals in the aqueous solution by irradiation of the ultrasonic waves, a polyacrylic film coating at least a part of the surface of the TiO2 particles and a polypeptide containing a preS1/S2 sequence of a hepatitis B virus bound to the polyacrylic film and specifically recognizing a liver tissue of a mammal. The dispersion particle diameter is within the range of 50 to 200 nm.

Inventors:

SHIMIZU NOBUAKI
OGINO CHIAKI
KURODA SHUNICHI

Application Number:

JP2007032765A

Publication Date:

August 28, 2008

Filing Date:

February 13, 2007

Export Citation:

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Assignee:

UNIV KANAZAWA

International Classes:

A61K9/16; A61K41/00; A61K47/30; A61K47/32; A61K47/42; A61K47/48; A61P35/00; A61K33/24; A61K39/29; C07K17/08

Attorney, Agent or Firm:

Sonoda Yoshitaka
Kobayashi Yoshinori

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