Title:
4-(ピペリジル)(2-ピリジル)メタノン-(E)-O-メチルオキシムおよびその塩の合成
Document Type and Number:
Japanese Patent JP4425632
Kind Code:
B2
Abstract:
In one embodiment, the present invention describes the synthesis of 4-(piperidyl) (2-pyridyl)methanone-(E)-O-methyloxime dihydrochloride, monohydrochloride and free base, and similar compounds, in high stereochemical purity.
Inventors:
C, Wensh
Riao, Hon Biao
Tsai, David Jay. S.
Riao, Hon Biao
Tsai, David Jay. S.
Application Number:
JP2003536228A
Publication Date:
March 03, 2010
Filing Date:
October 15, 2002
Export Citation:
Assignee:
Schering Corporation
International Classes:
C07D401/06; C07B61/00; C07B57/00
Foreign References:
| WO1998057950A1 |
Other References:
PALANI,A. et al,Discovery of 4-[(Z)-(4-Bromophenyl)(ethoxyimino)methyl]-1'-[(2,4-dimethyl- 3-pyridinyl)carbonyl]-4'-methyl-1,4'-bipiperidine N-Oxide (SCH 351125): An Orally Bioavailable Human CCR5 Antagonist for the Treatment of HIV Infection,Journal of Medicinal Chemistry,2001年,Vol.44, No.21,p.3339-3342
PIWINSKI,J.J. et al,Dual antagonists of platelet-activating factor and histamine. Identification of structural requirements for dual activity of N-acyl-4-(5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11- ylidene)piperidines,Journal of Medicinal Chemistry,1991年,Vol.34, No.1,p.457-461
RADL,S. et al,Synthesis and antinociceptive activity of some 3-chlorophenyl- and 6-chloro-2-pyridinyl derivatives,Collection of Czechoslovak Chemical Communications,1999年,Vol.64, No.2,p.377-388
PIWINSKI,J.J. et al,Dual antagonists of platelet-activating factor and histamine. Identification of structural requirements for dual activity of N-acyl-4-(5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11- ylidene)piperidines,Journal of Medicinal Chemistry,1991年,Vol.34, No.1,p.457-461
RADL,S. et al,Synthesis and antinociceptive activity of some 3-chlorophenyl- and 6-chloro-2-pyridinyl derivatives,Collection of Czechoslovak Chemical Communications,1999年,Vol.64, No.2,p.377-388
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita