Title:
脂質ナノ粒子とコルチコステロイドまたはビタミンD誘導体とを含む組成物
Document Type and Number:
Japanese Patent JP2014508796
Kind Code:
A
Abstract:
A pharmaceutical composition comprises, as a therapeutically active ingredient, a corticosteroid and/or vitamin D derivative incorporated as a solid solution or dispersion in lipid nanoparticles, said lipid nanoparticles being solid at ambient temperature and comprising a first lipid with a melting point above body temperature, the first lipid being a wax selected from the group consisting of esters of C12-24 alcohols and C12-24 fatty acids, glyceryl mono-, di- or triesters of C12-24 fatty acids, C12-24 fatty alcohols, and cholesterol, optionally a second lipid which is an oil at ambient temperature and miscible with the first lipid, and a pharmaceutically acceptable surfactant.
Inventors:
Louise Bastrum Jensen
Carsten Paterson
Carsten Paterson
Application Number:
JP2014500411A
Publication Date:
April 10, 2014
Filing Date:
March 23, 2012
Export Citation:
Assignee:
Leo Pharma Actiesl Scab
International Classes:
A61K31/573; A61K9/127; A61K9/51; A61K31/58; A61K31/592; A61K47/06; A61K47/10; A61K47/14; A61K47/18; A61K47/24; A61K47/28; A61K47/32; A61K47/34; A61K47/36; A61K47/38; A61K47/44; A61P17/00; A61P17/02; A61P17/06; A61P17/08
Domestic Patent References:
| JP2011504870A | 2011-02-17 |
Foreign References:
| WO1999044617A1 | 1999-09-10 |
Other References:
R. SIVARAMAKRISHNAN ET AL.: "Glucocorticoid entrapment into lipid carriers − characterisation by parelectric spectroscopy and i", JOURNAL OF CONTROLLED RELEASE, vol. 97, no. 3, JPN6015053023, 2004, pages 493 - 502, XP004519513, DOI: doi:10.1016/j.jconrel.2004.04.001
ZHANG, JIN ET AL.: "Percutaneous Permeation of Betamethasone 17-ValerateIncorporated in Lipid Nanoparticles", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 100, no. 3, JPN6015053024, 2011, pages 896 - 903, XP055035595, DOI: doi:10.1002/jps.22329
ZHANG, JIN ET AL.: "Percutaneous Permeation of Betamethasone 17-ValerateIncorporated in Lipid Nanoparticles", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 100, no. 3, JPN6015053024, 2011, pages 896 - 903, XP055035595, DOI: doi:10.1002/jps.22329
Attorney, Agent or Firm:
Aoyama Aoi
Takuji Yamada
Michiko Matsutani
Yasushi Ochiai
Takuji Yamada
Michiko Matsutani
Yasushi Ochiai