Title:
リポキシゲナーゼ阻害剤とシクロデキストリンとを含む組成物
Document Type and Number:
Japanese Patent JP2009516001
Kind Code:
A
Abstract:
The present invention is directed to formulations of inclusion complexes of lipoxygenase inhibitors and cyclodextrins having a therapeutically effective concentration of the lipoxygenase inhibitor, methods of making the same and methods of treating disease states using the same. Forming cyclodextrin complexes permits the enhancement of the aqueous solubility of lipoxygenase inhibitors which allows higher concentrations of the lipoxygenase in solution. Aqueous formulations of lipoxygenase inhibitors-cyclodextrin complexes are suitable for parenteral or oral administration for treating and/or preventing inflammatory disease states. The aqueous formulations can be lyophilized to prolong storage stability, assist in oral administration and/or provide for convenient and economical packaging.
Inventors:
Kip, James E.
Gupta, Pramod
Gupta, Pramod
Application Number:
JP2008541464A
Publication Date:
April 16, 2009
Filing Date:
November 15, 2006
Export Citation:
Assignee:
BAXTER INTERNATIONAL INCORP0RATED
BAXTER HEALTHCARE S.A.
BAXTER HEALTHCARE S.A.
International Classes:
A61K47/48; A61K9/08; A61K9/19; A61K31/381; A61K47/12; A61K47/40; A61P1/04; A61P7/06; A61P9/10; A61P9/14; A61P11/02; A61P11/06; A61P11/16; A61P17/06; A61P17/10; A61P19/02; A61P19/06; A61P29/00; A61P31/12; A61P35/00; A61P43/00
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita