COMPOSITION HAVING ACTIVITY FOR REGULATING EXPRESSION OF iNOS

Title:

COMPOSITION HAVING ACTIVITY FOR REGULATING EXPRESSION OF iNOS

Document Type and Number:

Japanese Patent JP2008013550

Kind Code:

A

Abstract:

To provide a composition targeting the regulation of the expression of iNOS (inducible nitric oxide synthase) and originated from a culture product of basidiomycete.

The expression of the iNOS can be regulated by using the composition originated from the culture product of the basidiomycete, and the composition is useful for biophylaxis, and therapy and prophylaxis of a disease associated with the excess production of NO, e.g. carcinogenesis, inflammatory disease, endotoxin shock caused by bacterial infection or the like.

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Inventors:

OKUMURA TADAYOSHI
NISHIZAWA MIKIO
KAMIYAMA YASUO
WAKAMEI KOJI
MIURA TAKETO

Application Number:

JP2007151892A

Publication Date:

January 24, 2008

Filing Date:

June 07, 2007

Export Citation:

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Assignee:

AMINO UP CHEMICAL CO LTD
UNIV KANSAI MEDICAL

International Classes:

A61K36/07; A61P7/00; A61P29/00; A61P35/00; A61P43/00; C12N15/09

Domestic Patent References:

JPH10139670A	1998-05-26
JP2007112750A	2007-05-10

Foreign References:

WO2006044616A2

2006-04-27

Other References:

JPN6012049205; ＱＵＡＮＧ　Ｄａｎｇ　ｅｔ　ａｌ: 'Ｉｎｅｄｉｂｌｅ　Ｍｕｓｈｒｏｏｍｓ：　Ａ　Ｇｏｏｄ　Ｓｏｕｒｃｅ　ｏｆ　Ｂｉｏｌｏｇｉｃａｌｌｙ　Ａｃｔｉｖｅ　Ｓｕｂｓｔａｎｃｅｓ' Ｃｈｅｍ　ＲｅｃＶｏｌ．６，Ｎｏ．２, 200604, Ｐａｇｅ．７９-９９
JPN6012049202; Ｂｏｒ，Ｊｕｎｇ-Ｙｉ　ｅｔ　ａｌ: 'Ｅｖａｌｕａｔｉｏｎ　ｏｆ　Ａｎｔｉｏｘｉｄａｎｔ　Ａｃｔｉｖｉｔｙ　ａｎｄ　Ｉｎｈｉｂｉｔｏｒｙ　Ｅｆｆｅｃｔ　ｏｎ　Ｎｉｔｒｉｃ　Ｏｘｉｄｅ　　Ｐｒｏｄｕｃｔｉｏｎ　ｏｆ　Ｓｏｍｅ　Ｃｏｍｍｏｎ' Ｊｏｕｒｎａｌ　ｏｆ　Ａｇｒｉｃｕｌｔｕｒａｌ　ａｎｄ　Ｆｏｏｄ　Ｃｈｅｍｉｓｔｒｙ５４（５）, 200605, ｐｐ．１６８０-１６８６
JPN6012064163; 松井康輔　他: '病態肝のｉＮＯＳ誘導におけるＡＨＣＣの効果' 日本外科学会雑誌Ｖｏｌ．１０７，臨時増刊号（２）, 20060305, Ｐａｇｅ．４５４

Attorney, Agent or Firm:

Kunihisa Landlord
Atsushi Hayashi

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