COMPOSITION FOR LONG-ACTING PEPTIDE ANALOG

Title:

COMPOSITION FOR LONG-ACTING PEPTIDE ANALOG

Document Type and Number:

Japanese Patent JP2014062128

Kind Code:

A

Abstract:

To provide a composition of a complex containing a biologically active peptide and a formulation and the use of the same.

The present invention relates to a treatment method for increasing a blood flow to various organs under reduced blood volume and reduced blood pressure and increasing a level of a factor VIII and a plasminogen activator in blood, using a group of novel long-acting vasopressin analogs and formulations and compounds of the same. More specifically, the present invention relates to vasopressin and a biologically active polypeptide derivative of the vasopressin, obtained by modification of forming a covalent bond at a binding site so as to generate a long-acting analog of the polypeptide, considered to act by a controlled release of active vasopressin or a vasopressin derivative.

Inventors:

GERARDO M CASTILLO
ELIJAH M BOLOTIN
CHAN ELAINE K

Application Number:

JP2014001389A

Publication Date:

April 10, 2014

Filing Date:

January 08, 2014

Export Citation:

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Assignee:

PHARMAIN CORP

International Classes:

A61K38/22; A61P1/16; A61P7/00; A61P9/00; A61P9/02; A61P9/08; A61P13/12; A61P31/04; C07K5/083; C07K7/06; C07K7/08; C07K14/00

Domestic Patent References:

JP2005524657A	2005-08-18
JP5683951B2	2015-03-11

Foreign References:

WO2002024213A2	2002-03-28
WO2007076371A2	2007-07-05
WO2006042152A2	2006-04-20
WO2002020033A1	2002-03-14
WO2002004015A1	2002-01-17

Other References:

JPN6015010819; Ｌａｎｃｅｔ，　２００２，　Ｖｏｌ．３５９，　ｐ．１２０９-１２１０

Attorney, Agent or Firm:

Hidesaku Yamamoto
Natsuki Morishita

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