COMPOSITION FOR MANIPULATING LIFESPAN AND STRESS RESPONSE OF CELLS AND ORGANISMS

Japanese Patent JP2007326872

A

To provide a method and a composition for modulating the activity of sirtuin deacetylase protein family members, p53 activity, apoptosis, and lifespan and sensitivity to stress of cells and organisms.

A method for protecting cells from apoptosis comprises a step of bringing a cell into contact with a sirtuin activating compound which bonds to SIRT1 of the cell to increase the deacetylase activity of the SIRT1, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or a method for rendering cells sensitive to apoptosis comprises a step of bringing a cell into contact with an activating compound which bonds to SIRT1 of the cell to decrease the deacetylase activity of the SIRT1 for example a sirtuin inhibitory compound, such as a sphingolipid, e.g., sphingosine.

COPYRIGHT: (C)2008,JPO&INPIT

SINCLAIR DAVID A
HOWITZ KONRAD T
ZIPKIN ROBERT E

JP2007203287A

December 20, 2007

August 03, 2007

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UNIV HARVARD
BIOMOL INTERNATL LP

A61K45/00; A61K8/34; A61K8/35; A61K8/49; A61K31/00; A61K31/05; A61K31/12; A61K31/175; A61K31/352; A61K31/353; A61K36/87; A61K45/06; A61P1/16; A61P3/06; A61P7/06; A61P9/00; A61P9/04; A61P9/08; A61P9/10; A61P9/12; A61P9/14; A61P17/00; A61P17/04; A61P17/06; A61P17/08; A61P17/12; A61P17/14; A61P17/16; A61P19/02; A61P21/00; A61P25/00; A61P25/02; A61P25/16; A61P25/28; A61P27/02; A61P27/06; A61P27/12; A61P27/14; A61P29/00; A61P31/12; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; A61Q19/08; C12N9/16; C12Q1/02; C12Q1/44

JP2001048722A	2001-02-20
JP2003137727A	2003-05-14

Mizuno Yuuki

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