Title:
COMPOSITION AND METHOD FOR BIOSYNTHESIS OF 1,4-BUTANEDIOL AND ITS PRECURSOR
Document Type and Number:
Japanese Patent JP2020072661
Kind Code:
A
Abstract:
To provide compositions and methods for biosynthesis of 1,4-butanediol and its precursors.SOLUTION: The invention provides a non-naturally occurring microbial biocatalyst including a microbial organism having a 4-hydroxybutanoic acid (4-HB) biosynthetic pathway having at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase, or α-ketoglutarate decarboxylase, wherein the exogenous nucleic acid is expressed in sufficient amounts to produce monomeric 4-hydroxybutanoic acid (4-HB).SELECTED DRAWING: None
Inventors:
BURK MARK J
VAN DIEN STEPHEN J
BURGARD ANTHONY
NIU WEI
VAN DIEN STEPHEN J
BURGARD ANTHONY
NIU WEI
Application Number:
JP2019188459A
Publication Date:
May 14, 2020
Filing Date:
October 15, 2019
Export Citation:
Assignee:
GENOMATICA INC
International Classes:
C12N1/21; C12N1/15; C12N1/19; C12N9/00; C12N9/02; C12N9/10; C12N9/12; C12N15/52; C12N15/53; C12N15/54; C12P7/18; C12P7/42
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita