Title:
COMPOSITION AND METHOD FOR DEALING WITH ANTIBACTERIAL AGENT RESISTANT BACTERIUM
Document Type and Number:
Japanese Patent JP2018076338
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a composition containing a bacterium invasion promotor for sensitizing a bacterium to an antibacterial agent and a medicine for inhibiting antibacterial agent resistant, and a method.SOLUTION: A step of specifying a bacterium and an antibacterial agent resistant profile of the bacterium, and adjusting a method for the specifying can be included. An invasion promotor to be provided is cyclic poly monoguanide/polyguanidine, polybiguanide, and is preferably illustratively polyhexamethylene biguanide (PHMB) and polyhexamethylene guanide (PHMG). In a composition, a pharmaceutical composition/formulation and a method for medical usage thereof, an exemplary medicine which inhibits antibacterial agent resistant is a medicine which binds to an antibacterial agent resistant determination factor such as beta-lactamase, PBP2a, NDM-1, and Vim2, and inhibits the antibacterial agent resistant determination factor.SELECTED DRAWING: Figure 2
Inventors:
RIDDEN JOHN
LIAM GOOD
LIAM GOOD
Application Number:
JP2017236029A
Publication Date:
May 17, 2018
Filing Date:
December 08, 2017
Export Citation:
Assignee:
BLUEBERRY THERAPEUTICS LTD
International Classes:
A61K45/06; A61K31/424; A61K31/7088; A61K31/785; A61K38/16; A61P31/04; A61P43/00
Domestic Patent References:
JP2007532490A | 2007-11-15 | |||
JP2008540544A | 2008-11-20 | |||
JP2005505529A | 2005-02-24 | |||
JP6312806B2 | 2018-04-18 | |||
JPH05201878A | 1993-08-10 |
Foreign References:
WO2004045629A1 | 2004-06-03 | |||
WO2012035283A1 | 2012-03-22 | |||
WO2003028762A1 | 2003-04-10 |
Other References:
JOURNAL OF MICROBIOLOGICAL METHODS, vol. 54, JPN6016043438, 2003, pages 111 - 115, ISSN: 0004249669
臨床と微生物, vol. 36, JPN6016043439, 2009, pages 610 - 102, ISSN: 0004249670
呼吸, vol. 6, no. 6, JPN6016043440, 1987, pages 632 - 636, ISSN: 0004249671
臨床と微生物, vol. 36, JPN6016043439, 2009, pages 610 - 102, ISSN: 0004249670
呼吸, vol. 6, no. 6, JPN6016043440, 1987, pages 632 - 636, ISSN: 0004249671
Attorney, Agent or Firm:
Masayuki Masabayashi
Hayashi Ichiyoshi
Tetsuo Shiba
Iwaike Mitsuru
Hayashi Ichiyoshi
Tetsuo Shiba
Iwaike Mitsuru