To obtain a composition capable of promoting the gel shrinkage in its initial stages in a three-dimensional collagen shrinkage system, having wound-closing activities at the early time in the wound-curing stage, and useful for promoting the cure of the wound in the wound-curing process by a new mechanism of action by making the composition include a specific polypeptide.
This composition contains a polypeptide belonging to a midkine(MK) family, preferably a midkine protein as an active ingredient. For example, the polypeptide can be prepared by formulating the polypeptide with a general vehicle, diluent or carrier to provide a preparation such as a tablet and a capsule. The preparation can includes at least one non-fibrotic growth factor or the like. An effective daily oral dose is about 0.1-1,000 mg and the dose is administered once or by dividing the dose up to about three times.
HATAKE KENICHIRO
UEDA MINORU
MURAMATSU TAKASHI
MURAMATSU TOSHIKO
IKEMATSU SHINYA
ODA MUNEHIRO
SAKUMA SADATOSHI
MURAMATSU TAKASHI
| JPH10251158A | 1998-09-22 | |||
| JPH10251133A | 1998-09-22 | |||
| JPH09157183A | 1997-06-17 | |||
| JP2002512200A | 2002-04-23 |