COMPOSITION FOR TREATING IMMUNITY-RELATED DISEASE AND METHOD

Japanese Patent JP2006197937

A

To provide a method for diagnosing or treating the immunity-related diseases of a mammal including human being.

A polypeptide having a specific amino acid sequence and having a T-lymphocyte proliferation-inhibiting activity. A nucleotide sequence encoding PRO polypeptide. A vector containing the sequence. A host containing the vector and expressing the polypeptide. A chimera molecule with an epitope tag sequence or immune globulin different kind polypeptide, fused with the polypeptide. An antibody to be specifically bound to the polypeptide, or its fragment. These substances are useful for medicinal compositions or kits for diagnosing immune-related diseases.

Sherman, Fong
Goddard, Audrey
Godowsky, Paul J.
Grimaldi, Christopher J.
Gurney, Austin L.
Hillan, Kenneth J.
Tumas, Daniel
Watanabe, Colin K.
Wood, William I.
Zhang, Zemin

JP2006000013034

August 03, 2006

January 20, 2006

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GENENTECH INC

C12N15/09; A61K38/00; A61K38/17; A61K39/395; A61P1/04; A61P1/16; A61P3/10; A61P5/14; A61P7/04; A61P7/06; A61P9/00; A61P11/00; A61P11/02; A61P11/06; A61P13/12; A61P17/00; A61P17/04; A61P17/06; A61P19/02; A61P21/00; A61P25/00; A61P25/02; A61P29/00; A61P31/14; A61P31/20; A61P35/00; A61P37/00; A61P37/06; A61P37/08; A61P43/00; C07K14/47; C07K16/00; C07K16/18; C07K19/00; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12N15/62; C12P21/02; C12Q1/02; C12Q1/68; G01N33/53; C12P21/08; C12N15/09; A61K38/00; A61K38/17; A61K39/395; A61P1/00; A61P3/00; A61P5/00; A61P7/00; A61P9/00; A61P11/00; A61P13/00; A61P17/00; A61P19/00; A61P21/00; A61P25/00; A61P29/00; A61P31/00; A61P35/00; A61P37/00; A61P43/00; C07K14/435; C07K16/00; C07K16/18; C07K19/00; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12N15/62; C12P21/02; C12Q1/02; C12Q1/68; G01N33/53; C12P21/08

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