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Title:
癌の診断および治療のための組成物および方法
Document Type and Number:
Japanese Patent JP2021526808
Kind Code:
A
Abstract:
本発明は、組織リモデリングおよび/または血管新生を特徴とする疾患、特に頭頸部癌、脳の癌、結腸直腸癌、肺癌、前立腺癌および乳癌などの癌性疾患のようなフィブロネクチンエクストラドメインB(EDB)を発現する疾患の診断および治療に関する。より具体的には、本発明は、フィブロネクチンエクストラドメインBを標的とするペプチドに関する。

Inventors:
Sahin, Uguru
Louis, Bonnie Gabby
Salomon, Naja
Vustehube-Roche, Joycelin
Danesudar, Matin
Schmalt, Hans-Ulrich
Fiedler, Marx
Application Number:
JP2020568252A
Publication Date:
October 11, 2021
Filing Date:
June 06, 2019
Export Citation:
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Assignee:
BIONTECH SE
International Classes:
C12N15/12; A61K35/12; A61K38/16; A61K47/64; A61K48/00; A61K49/00; A61P35/00; C07K14/78; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/62; C40B40/10; G01N33/531; G01N33/574
Domestic Patent References:
JP2012505929A2012-03-08
JP2010500875A2010-01-14
Foreign References:
WO2017049009A12017-03-23
WO2016022597A12016-02-11
WO2016146639A12016-09-22
Other References:
GEBAUER, MICHAELA ET AL.: "Combinatorial Design of an Anticalin Directed against the Extra-Domain B for the Specific Targeting", J. MOL. BIOL., vol. 425, JPN6023016100, 2013, pages 780 - 802, ISSN: 0005045209
PARK, JINHO ET AL.: "Fibronectin extra domain B-specific aptide conjugated nanoparticles for targeted cancer imaging", JOURNAL OF CONTROLLED RELEASE, vol. 163, JPN6023016101, 3 September 2012 (2012-09-03), pages 111 - 118, ISSN: 0005045210
MAAB, FRANZISKA ET AL.: "Cystine-knot peptides targeting cancer-relevant human cytotoxic T lymphocyte associated antigen 4 (C", JOURNAL OF PEPTIDE SCIENCE, vol. 21, JPN6023016102, 10 May 2015 (2015-05-10), pages 651 - 660, ISSN: 0005045211
Attorney, Agent or Firm:
Shinji Hayami