Title:
癌の診断および処置のための組成物および方法
Document Type and Number:
Japanese Patent JP5535633
Kind Code:
B2
Abstract:
An isolated antibody that specifically binds to an extracellular domain of human DLL4 and affects growth of a tumor comprising cancer stem cells is described. Also described is a method of treating cancer comprising administering a therapeutically effective amount of an anti-DLL4 antibody.
Inventors:
Gurney austin
Hoi Timothy
Satyaal Sanjeev
Accel Rod Fumiko
Hoi Timothy
Satyaal Sanjeev
Accel Rod Fumiko
Application Number:
JP2009530419A
Publication Date:
July 02, 2014
Filing Date:
September 28, 2007
Export Citation:
Assignee:
Oncomed Pharmaceuticals Incorporated
International Classes:
A61K39/395; C07K16/30; A61K45/00; A61P35/00; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12P21/08
Domestic Patent References:
| JP2005511754A |
Other References:
Leukemia,2004年,Vol.18,p.788-797
日本癌学会学術総会記事,2006年 8月28日,Vol.65,p.311-312,P-619
すい臓,2006年 6月10日,Vol.21, No.3,p.249,O-69
GENES & DEVELOPMENT,2000年,Vol.14,p.1313-1318
日本癌学会学術総会記事,2006年 8月28日,Vol.65,p.311-312,P-619
すい臓,2006年 6月10日,Vol.21, No.3,p.249,O-69
GENES & DEVELOPMENT,2000年,Vol.14,p.1313-1318
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Kazuya Kawamoto